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Bimagrumab-OGreen (CAT#: ADC-FL-017)

This product is comprised of an anti-ACVR2B monoclonal antibody (Bimagrumab) labeled with Oregon green. Oregon green is a green-fluorescent dye and it's excitation/emission is 501/526 nm.

  • TARGET
  • ANTIBODY
  • DYE
  • Name
  • ACVR2B
  • Alternative Names
  • ACVR2B; activin A receptor, type IIB; activin receptor type-2B; ActR IIB; HTX4; ACTRIIB; ActR-IIB;
  • Overview
  • Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
  • Overview
  • Human Anti-ACVR2B IgG1-lambda antibody, Bimagrumab
  • Generic name
  • Bimagrumab
  • Species Reactivity
  • Human
  • Name
  • Oregon green
  • Color
  • Green
  • Excitation⁄Emission (nm)
  • 501/526

For Research Use Only. NOT FOR CLINICAL USE.

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ADC-W-653 Anti-ACVR2B (Bimagrumab)-MC-Vc-PAB-MMAE ADC MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE
ADC-W-652 Anti-ACVR2B (Bimagrumab)-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-650 Anti-ACVR2B (Bimagrumab)-SMCC-DM1 ADC SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
ADC-W-654 Anti-ACVR2B (Bimagrumab)-MC-Vc-PAB-SN38 ADC MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin)
ADC-W-651 Anti-ACVR2B (Bimagrumab)-SPDB-DM4 ADC SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)

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