What is Biotin-PEG-maleimide, and what are its primary applications?

Biotin-PEG-maleimide is a bifunctional reagent used for bioconjugation, connecting thiol-containing molecules like proteins and antibodies to biotinylated structures, often for drug delivery or ADC development.

How does the maleimide group in Biotin-PEG-maleimide function in conjugation reactions?

The maleimide group reacts with thiol groups in proteins or peptides, forming stable thioether bonds, which are essential for the conjugation of biomolecules in ADCs and other drug delivery systems.

What are the typical lengths of PEG chains in Biotin-PEG-maleimide?

Biotin-PEG-maleimide comes in various PEG chain lengths (PEG1-PEGn), allowing researchers to choose the optimal length for solubility, flexibility, and reduced steric hindrance in their experiments.

Can Biotin-PEG-maleimide be used in multi-functional conjugates?

Yes, Biotin-PEG-maleimide can be used to create multifunctional conjugates, allowing for the attachment of multiple payloads or targeting moieties, improving the versatility of drug delivery systems.

How does PEG length in Biotin-PEG-maleimide affect its function in ADCs?

Longer PEG chains reduce steric hindrance and increase solubility, improving circulation time and reducing immune recognition, making it suitable for designing more stable ADCs.

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Biotin-PEG-maleimide (PEG1-PEGn)

Biotin-PEG-maleimide (PEG1-PEGn) (CAT#: ADC-L-600)

Biotin-PEG-maleimide (PEG1-PEGn) is a linker for bio-conjugation that contains a biotin and a terminal maleimide group linked through a linear PEG chain.

Product Information

CAS NO
305372-39-8

Description
Biotin-PEG-maleimide (PEG1-PEGn) is a linker for bio-conjugation that contains a biotin and a terminal maleimide group linked through a linear PEG chain.

Molecular Weight
525.6

Purity
95%

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Customer Reviews FAQ

Excellent

Biotin-PEG-maleimide was an essential linker in our bio-conjugation assays. The biotin and maleimide groups facilitated efficient protein labeling, allowing us to achieve precise and stable conjugations.

Excellent

In our ADC research, Biotin-PEG-maleimide enhanced the stability of our drug conjugates. The PEG chain provided flexibility while maintaining strong bio-conjugation between the antibody and drug payload.

Excellent

We used Biotin-PEG-maleimide in several bio-conjugation experiments, and it worked efficiently to link proteins with small molecules. The PEG chain ensured solubility and reduced aggregation issues.

Excellent

Biotin-PEG-maleimide was indispensable in our bio-conjugation work. Its biotin group provided a reliable method for streptavidin binding, while the PEG chain minimized steric hindrance during conjugation.

Excellent

Biotin-PEG-maleimide provided a reliable means of conjugating proteins to biotinylated surfaces. Its linear PEG chain minimized non-specific binding and allowed for consistent experimental outcomes in our lab.

Q: 1: What is Biotin-PEG-maleimide, and what are its primary applications?
A: Biotin-PEG-maleimide is a bifunctional reagent used for bioconjugation, connecting thiol-containing molecules like proteins and antibodies to biotinylated structures, often for drug delivery or ADC development.
Q: 2: How does the maleimide group in Biotin-PEG-maleimide function in conjugation reactions?
A: The maleimide group reacts with thiol groups in proteins or peptides, forming stable thioether bonds, which are essential for the conjugation of biomolecules in ADCs and other drug delivery systems.
Q: 3: What are the typical lengths of PEG chains in Biotin-PEG-maleimide?
A: Biotin-PEG-maleimide comes in various PEG chain lengths (PEG1-PEGn), allowing researchers to choose the optimal length for solubility, flexibility, and reduced steric hindrance in their experiments.
Q: 4: Can Biotin-PEG-maleimide be used in multi-functional conjugates?
A: Yes, Biotin-PEG-maleimide can be used to create multifunctional conjugates, allowing for the attachment of multiple payloads or targeting moieties, improving the versatility of drug delivery systems.
Q: 5: How does PEG length in Biotin-PEG-maleimide affect its function in ADCs?
A: Longer PEG chains reduce steric hindrance and increase solubility, improving circulation time and reducing immune recognition, making it suitable for designing more stable ADCs.

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