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- Anti-FUT3-hydrazone-doxorubicin ADC
Anti-FUT3-hydrazone-doxorubicin ADC (CAT#: ADC-W-423)
This ADC product is comprised of an anti-FUT3 monoclonal antibody (clone cBR96) conjugated via a hydrazone linker to adoxorubicin. The doxorubicin is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, doxorubicin binds to DNA, causes DNA damage.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Antibody clone #
- BR96
- Name
- FUT3
- Alternative Names
- FUT3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); LE; Les; FT3B; CD174; FucT-III; galactoside 3(4)-L-fucosyltransferase; Lewis FT; fucosyltransferase III; alpha-(1,3/1,4)-fucosyltransferase; blood group Lewis alpha-4-f
- Target Entrez Gene ID
- 2525
- Target UniProt ID
- A8K737
- Overview
- The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
- Overview
- Anti-FUT3 lgG3 Antibody, clone # BR96
- Clone #
- BR96
- Species Reactivity
- Mouse
- Name
- hydrazone
- Description
- Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3-7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0-6.5) and lysosomal (pH 4.5-5.0) compartments of the cell.
- Name
- doxorubicin
- Description
- Doxorubicin is a type of anti-cancer chemotherapy drug called an anthracycline. Doxorubicin works by blocking an enzyme called TopoisomeraseⅡthat cancer cells need to divide and grow.
For Research Use Only. NOT FOR CLINICAL USE.
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Published Data
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Quick Links
Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-459 | Anti-FUT3-AcBut-CalichDMH ADC-2 | AcBut [-(4' acetyl phenoxy) butanoic acid] | CalichDMH |
| ADC-W-604 | Anti-FUT3-Mc-VC-PABC-MMAF ADC-3 | MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-463 | Anti-FUT3-Mc-Dox ADC | Mc (maleimidocaproyl) | Doxorubicin |
| ADC-W-424 | Anti-FUT3-VC-MMAE ADC-1 | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-338 | Anti-CD22 (Inotuzumab)-hydrazone-Calicheamicin ADC | hydrazone | calicheamicin |
| CAT# | Product Name | Linker | Payload |
| ADC-W-571 | Anti-ERBB2 (Trastuzumab)-DOX ADC | thiomaleamicacids-p-aminobenzyloxycarbonyl | doxorubicin |
| ADC-W-378 | Anti-CD74-hindered disulfide-Doxorubicin ADC | hindered disulfide | doxorubicin |
| ADC-W-600 | Anti-EGFR-doxorubicin ADC | polyethylene glycol linker | doxorubicin |
| ADC-W-581 | Anti-EpCAM-hydrazone-Doxorubicin ADC-2 | acid-cleavable hydrazone linker | doxorubicin |
| ADC-W-602 | Anti-FOLR1-S-S-Dox ADC | disulfide (“S-S”) linker | doxorubicin |
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