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Anti-TACSTD2-VC-MMAD ADC-2 (CAT#: ADC-W-568)

This ADC product is comprised of an anti-TACSTD2 monoclonal antibody (clone C16) conjugated via a VC linker to MMAD. The MMAD is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAD binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • Product Information
  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Antibody clone #
  • C16
  • Name
  • TACSTD2
  • Alternative Names
  • TACSTD2; tumor-associated calcium signal transducer 2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic ca
  • Target Entrez Gene ID
  • 4070
  • Overview
  • This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.
  • Overview
  • Anti-TACSTD2 Antibody, clone # C16
  • Clone #
  • C16
  • Species Reactivity
  • Human
  • Name
  • VC (valine-citrulline)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Name
  • MMAD (monomethyl auristatin D)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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CAMouse™-Fully Human Antibody Generation Platform
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Same Target Same Linker Same Payload
CAT# Product Name Linker Payload
ADC-W-539 Anti-TACSTD2-PEG6-Aur3377 ADC-2 Amino-PEG6-based linker Aur3377
ADC-W-293 Anti-TACSTD2-AcLys-VC-PABC-0101 ADC-1 AcLys-VC- PABC (Acetyl-lysine-valine-citrulline-p-aminobenzyloxycarbonyl) 2-methylalanyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide)
ADC-W-292 Anti-TACSTD2-PEG6-MMAD ADC-1 PEG6 ((Propylene Glycol)-6-propionyl) MMAD (monomethyl auristatin D)
ADC-W-538 Anti-TACSTD2-PEG6-MMAD ADC-2 Amino-PEG6-based linker MMAD (monomethyl auristatin D)
ADC-W-563 Anti-TACSTD2-VC-PABC-Aur0101 ADC-2 VC-PABC (valine-citrulline-p-aminobenzylcarbamate) Aur0101
CAT# Product Name Linker Payload
ADC-AA-048 Protein G-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
ADC-W-536 Anti-EDNRB (endothelin B)-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
ADC-W-514 Anti-ERBB2 (Trastuzumab)-VC-DUBA ADC VC (valine-citrulline) seco-DUBA (DUocarmycin hydroxyBenzamide Azaindole)
ADC-W-475 Anti-CA9-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
ADC-AA-052 Protein A-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
CAT# Product Name Linker Payload
ADC-W-167 Anti-TPBG-VC-MMAD ADC-11 VC (valine-citrulline) MMAD (monomethyl auristatin D)
ADC-W-570 Anti-TACSTD2-Mc-VC-MMAD ADC-2 Mc-VC (maleimidocaproyl-valine-alanine) MMAD (monomethyl auristatin D)
ADC-W-632 Anti-ERBB2 (trastuzumab)-Aminocaproyl-MMAD ADC Aminocaproyl MMAD (monomethyl auristatin D)
ADC-W-413 Anti-ERBB2 (Trastuzumab)-hydroxyl amino PEG linker-MMAD (monomethyl auristatin D) ADC hydroxyl amino PEG linker MMAD (monomethyl auristatin D)
ADC-W-408 Anti-ERBB2 (Trastuzumab)-MMAD ADC Non-Cleavable hydroxyl amino PEG linker MMAD (monomethyl auristatin D)

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