Anti-TNFRSF8-β-glucuronide-Camptothecin Analog ADC-14 (CAT#: ADC-W-349)

Name: Anti-TNFRSF8-β-glucuronide-Camptothecin Analog ADC-14
SKU: ADC-W-349
Rating: 5 (1 reviews)

This ADC product is comprised of an anti-TNFRSF8 monoclonal antibody (CA10) conjugated via a β-glucuronide linker to a Camptothecin Analog.

Alternative Names
TNFRSF8; tumor necrosis factor receptor superfamily, member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30;

Overview
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Description
β-Glucuronide linkers belong to Enzymatically cleavable linkers, which have expected stability and provide facile release of the active drug. The cleavage of the β-glucuronide glycosidic bond relies on lysosomal enzyme β-glucuronidase, and this enzyme is abundantly present within lysosomes and is overexpressed in some tumor types, while the enzyme activity outside cells is low.

Description
Calicheamicin,produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

For Research Use Only. NOT FOR CLINICAL USE.

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Same Target Same Linker Same Payload

CAT#	Product Name	Linker	Payload
ADC-W-2343	Anti-TNFRSF8 (Brentuximab )-SMCC-DM1 ADC	SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)	DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
ADC-W-1890	Anti-TNFRSF8 (Iratumumab)-MC-Vc-PAB-SN38 ADC	MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)	SN-38 (7-ethyl-10-hydroxycamptothecin)
ADC-W-355	Anti-TNFRSF8 -Mc-MMAF ADC-12	MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)	MMAF (Monomethyl auristatin F)
ADC-W-1888	Anti-TNFRSF8 (Iratumumab)-MC-MMAF ADC	MC (maleimidocaproyl)	MMAF
ADC-W-509	Anti-TNFRSF8 (Brentuximab)-VC-PABC-MMAE ADC	VC-PABC(valine-citrulline-p-aminobenzylcarbamate)	MMAE (Monomethyl auristatin E)

CAT#	Product Name	Linker	Payload
ADC-W-374	Anti-CD70-β-glucuronide-MMAE ADC-5	β-glucuronide linker	MMAE (Monomethyl auristatin E)
ADC-W-351	Anti-TNFRSF8-β-glucuronide-MMAE ADC-14	β-glucuronide linker	MMAE (Monomethyl auristatin E)
ADC-W-375	Anti-CD70-β-glucuronide-MMAF ADC-5	β-glucuronide linker	MMAF (Monomethyl auristatin F)
ADC-W-353	Anti-TNFRSF8-β-glucuronide-doxorubicin propyloxazoline ADC-12	β-glucuronide linker	doxorubicin propyloxazoline (DPO)
ADC-W-350	Anti-TNFRSF8-β-glucuronide-CBI Minor Groove Binder ADC-14	β-glucuronide linker	CBI Minor Groove Binder

CAT#	Product Name	Linker	Payload
ADC-W-372	Anti-CD70-β-glucuronide-Camptothecin Analog ADC-5	β-glucuronide linker	Camptothecin Analog

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