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- Anti-TNFRSF8-β-glucuronide-CBI Minor Groove Binder ADC-14
Anti-TNFRSF8-β-glucuronide-CBI Minor Groove Binder ADC-14 (CAT#: ADC-W-350)
This ADC product is comprised of an anti-TNFRSF8 monoclonal antibody (CA10) conjugated via a β-glucuronide linker to a CBI Minor Groove Binder.
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Name
- TNFRSF8
- Alternative Names
- TNFRSF8; tumor necrosis factor receptor superfamily, member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30;
- Target Entrez Gene ID
- 943
- Target UniProt ID
- A5D8T4
- Overview
- The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
- Overview
- Chimeric Anti-TNFRSF8 Antibody, cAC10
- Generic name
- cAC10
- Species Reactivity
- Human
- Name
- β-glucuronide linker
- Description
- β-Glucuronide linkers belong to Enzymatically cleavable linkers, which have expected stability and provide facile release of the active drug. The cleavage of the β-glucuronide glycosidic bond relies on lysosomal enzyme β-glucuronidase, and this enzyme is abundantly present within lysosomes and is overexpressed in some tumor types, while the enzyme activity outside cells is low.
- Name
- CBI Minor Groove Binder
For Research Use Only. NOT FOR CLINICAL USE.
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Same Linker
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| CAT# | Product Name | Linker | Payload |
| ADC-W-2343 | Anti-TNFRSF8 (Brentuximab )-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-2345 | Anti-TNFRSF8 (Brentuximab )-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-509 | Anti-TNFRSF8 (Brentuximab)-VC-PABC-MMAE ADC | VC-PABC(valine-citrulline-p-aminobenzylcarbamate) | MMAE (Monomethyl auristatin E) |
| ADC-W-2346 | Anti-TNFRSF8 (Brentuximab )-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-2347 | Anti-TNFRSF8 (Brentuximab )-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
| CAT# | Product Name | Linker | Payload |
| ADC-W-352 | Anti-TNFRSF8-β-glucuronide-MMAF ADC-12 | β-glucuronide linker | MMAF (Monomethyl auristatin F) |
| ADC-W-351 | Anti-TNFRSF8-β-glucuronide-MMAE ADC-14 | β-glucuronide linker | MMAE (Monomethyl auristatin E) |
| ADC-W-376 | Anti-CD70-β-glucuronide-doxorubicin ADC-5 | β-glucuronide linker | doxorubicin |
| ADC-W-375 | Anti-CD70-β-glucuronide-MMAF ADC-5 | β-glucuronide linker | MMAF (Monomethyl auristatin F) |
| ADC-W-353 | Anti-TNFRSF8-β-glucuronide-doxorubicin propyloxazoline ADC-12 | β-glucuronide linker | doxorubicin propyloxazoline (DPO) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-373 | Anti-CD70-β-glucuronide-CBI Minor Groove Binder ADC-5 | β-glucuronide linker | CBI Minor Groove Binder |
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