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- Anti-EPCAM (Edrecolomab)-MC-MMAF ADC
Anti-EPCAM (Edrecolomab)-MC-MMAF ADC (CAT#: ADC-W-1096)
This ADC product is comprised of an anti-EPCAM monoclonal antibody conjugated via a MC linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Name
- EPCAM
- Alternative Names
- EPCAM; epithelial cell adhesion molecule; antigen identified by monoclonal AUA1 , M4S1, MIC18, TACSTD1, tumor associated calcium signal transducer 1; 17 1A; 323/A3; CD326; CO 17A; EGP 2; EGP34; EGP40; Ep CAM; ESA; GA733 2; HEA125; KS1/4; KSA; Ly74; MH99;ාܰɫࢸงɵࣛݩɿࣽކʈटຬޣʒूʜ।༛ߜʥআདྷ߹ʯྉࠕʹো࿁࠲˂৭ࡏˌਐု˖ਲၦ࢈˟႞ࢥ˩ვࣂ˳ઙᄌࣟ˼ᅃࣻ̆ᅻघ̐ᆲव̙ଢᇩ॒̣ሠ८̭୧ቘঋ̶உন̀͊ዽৡ͓௰ጵ৾͝ఓ፬ਛͧవᎣਸͰᏚͺ౺ᐑੱ΄ಜᑉಾᒀફΗೡᒷેΡഃᓮΪഥᔦଁδൈᕝଞξ൪ᖔχඌᗋୗϑදᘃ୴ϛෑᘺஐϤෳᙱϮถᚨொϸุᛠ௧Ё๛ఃЋᝎఠЕຟចఽПໂួౚШ៴в༆ᠫಓм༩ᡢರхཋᢚ್яᣑ೩љྐᤈആѢྲണѬ࿔ീѶ൜ѿမ᧥൹҉ျඖғၞᩓඳҜႀාҦႢ᫂෬ҰჅฉҹყᬰฦӃᄉ᭨โӍᄬᮟӖᅎᯖӠᅰᰍນӪᆓ᱅ີӳᆵᱼ໒ӽᇗᲳԇᇺᳪ༌Ԑሜᴢ༨ԚሾᵙཅԤቡᶐརԭኃ᷇ཾԷእ᷿ྛՁወḶྸՊዪṭ࿕ՔጌẤ՞ጯỜဎէፑἓါձ፳Ὂ၈ջ᎖ᾁၤքᎸᾹႁ֎Ꮫ႞֘ᏽ‧Ⴛ֢ᐟ⁞თ֫ᑂₕჴֵᑤᄑֿᒆ℄ᄮᒩ℻ᅊגᓋⅲᅧלᓭ↪ᆄץᔐ⇡ᆡׯᔲ∘ᆽᕔ≏ᇚᕷ⊇ᇷ،ᖙ⊾ሔؖᖻ⋵ሰ؟ᗞ⌬ቍة
- Target Entrez Gene ID
- 4072
- Target UniProt ID
- P16422
- Overview
- This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.
- Overview
- Anti-EPCAM IgG2-kappa antibody, Edrecolomab
- Generic name
- Edrecolomab
- Host animal
- Mouse
- Species Reactivity
- Human
- Name
- MC (maleimidocaproyl)
- Description
- Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Name
- MMAF
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
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Published Data
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Quick Links
Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-1079 | Anti-EPCAM (Citatuzumab bogatox)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-1085 | Anti-EPCAM (Tucotuzumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-1084 | Anti-EPCAM (Tucotuzumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-1080 | Anti-EPCAM (Citatuzumab bogatox)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-1082 | Anti-EPCAM (Tucotuzumab)-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-485 | Anti-EphA2-Mc-MMAF ADC-1 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-478 | Anti-ENPP3-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-493 | Anti-CD19-Mc-MMAF ADC-3 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-2622 | Anti-NCAM1 (Lorvotuzumab )-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-2606 | Anti-ITGB3 (Tadocizumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| CAT# | Product Name | Linker | Payload |
| ADC-W-2573 | Anti-SLC34A2 (Lifastuzumab )-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-2561 | Anti-MSLN (Anetumab )-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-2591 | Anti-EGFR (Cetuximab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-AA-063 | Anti-HIgG(Fab)-N-MMAF ADC | Noncleavable linkers | MMAF |
| ADC-W-2585 | Anti-EGFR (Zalutumumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
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