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Anti-EPCAM (Edrecolomab)-MC-MMAF ADC (ADC-W-1096)

This ADC product is comprised of an anti-EPCAM monoclonal antibody conjugated via a MC linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

 ADC Target

  • Name
  • EPCAM
  • Alternative Names
  • EPCAM; epithelial cell adhesion molecule; antigen identified by monoclonal AUA1 , M4S1, MIC18, TACSTD1, tumor associated calcium signal transducer 1; 17 1A; 323/A3; CD326; CO 17A; EGP 2; EGP34; EGP40; Ep CAM; ESA; GA733 2; HEA125; KS1/4; KSA; Ly74; MH99;ාܰɫࢸง݌ɵࣛ฾ݩɿࣽ๵ކʈटຬޣʒू໤޿ʜ।༛ߜʥআདྷ߹ʯ঩ྉࠕʹো࿁࠲˂৭࿸ࡏˌਐု࡬˖ਲၦ࢈˟੔႞ࢥ˩੷ვࣂ˳ઙᄌࣟ˼઻ᅃࣻ̆૞ᅻघ̐଀ᆲव̙ଢᇩ॒̣୅ሠ८̭୧ቘঋ̶உ኏ন̀஬዆৅͊௎ዽৡ͓௰ጵ৾͝ఓ፬ਛͧవᎣਸͰ౗Ꮪ੔ͺ౺ᐑੱ΄ಜᑉ઎΍ಾᒀફΗೡᒷેΡഃᓮ૤Ϊഥᔦଁδൈᕝଞξ൪ᖔ଺χඌᗋୗϑදᘃ୴ϛෑᘺஐϤෳᙱ஭Ϯถᚨொϸุᛠ௧Ё๛᜗ఃЋ๽ᝎఠЕຟចఽПໂួౚШ໤៴౶в༆ᠫಓм༩ᡢರхཋᢚ್я཭ᣑ೩љྐᤈആѢྲ᤿ണѬ࿔᥷ീѶ࿷᦮൜ѿမ᧥൹҉ျ᨜ඖғၞᩓඳҜႀ᪋ාҦႢ᫂෬ҰჅ᫹ฉҹყᬰฦӃᄉ᭨โӍᄬᮟ๟Ӗᅎᯖ๼ӠᅰᰍນӪᆓ᱅ີӳᆵᱼ໒ӽᇗᲳ໯ԇᇺᳪ༌Ԑሜᴢ༨ԚሾᵙཅԤቡᶐརԭኃ᷇ཾԷእ᷿ྛՁወḶྸՊዪṭ࿕ՔጌẤ࿱՞ጯỜဎէፑἓါձ፳Ὂ၈ջ᎖ᾁၤքᎸᾹႁ֎Ꮫ῰႞֘ᏽ‧Ⴛ֢ᐟ⁞თ֫ᑂₕჴֵᑤ⃍ᄑֿᒆ℄ᄮ׈ᒩ℻ᅊגᓋⅲᅧלᓭ↪ᆄץᔐ⇡ᆡׯᔲ∘ᆽ׹ᕔ≏ᇚ؂ᕷ⊇ᇷ،ᖙ⊾ሔؖᖻ⋵ሰ؟ᗞ⌬ቍة
  • Target Entrez Gene ID
  • 4072
  • Overview
  • This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.

 ADC Antibody

  • Overview
  • Anti-EPCAM IgG2-kappa antibody, Edrecolomab
  • Generic name
  • Edrecolomab
  • Host animal
  • Mouse
  • Species Reactivity
  • Human

 ADC Linker

  • Name
  • MC (maleimidocaproyl)
  • Description
  • Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

 ADC payload drug

  • Name
  • MMAF
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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