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Anti-CD70 (clone h1F6)-β-glucuronide-Camptothecin Analog ADC (ADC-W-372)

This ADC product is comprised of an anti-CD70 monoclonal antibody (clone h1F6) conjugated via a β-glucuronide linker to a Camptothecin Analog. The Camptothecin Analog is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis.
  • Antibody clone #
  • h1F6

 ADC Target

  • Name
  • CD70
  • Alternative Names
  • CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;
  • Target Entrez Gene ID
  • 970
  • Overview
  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

 ADC Antibody

  • Overview
  • Humanized Anti-CD70 lgG1 Antibody, clone # h1f6
  • Clone #
  • h1F6
  • Species Reactivity
  • Human

 ADC Linker

  • Name
  • β-glucuronide linker
  • Description
  • β-Glucuronide linkers belong to Enzymatically cleavable linkers, which have expected stability and provide facile release of the active drug. The cleavage of the β-glucuronide glycosidic bond relies on lysosomal enzyme β-glucuronidase, and this enzyme is abundantly present within lysosomes and is overexpressed in some tumor types, while the enzyme activity outside cells is low.

 ADC payload drug

  • Name
  • Camptothecin Analog
  • Description
  • Calicheamicin,produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

For Research Use Only. NOT FOR CLINICAL USE.

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