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- Anti-CD70-β-glucuronide-CBI Minor Groove Binder ADC-5
Anti-CD70-β-glucuronide-CBI Minor Groove Binder ADC-5 (CAT#: ADC-W-373)
This ADC product is comprised of an anti-CD70 monoclonal antibody (clone h1F6) conjugated via a β-glucuronide linker to a CBI Minor Groove Binder. The CBI Minor Groove Binder is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Antibody clone #
- h1F6
- Name
- CD70
- Alternative Names
- CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;
- Target Entrez Gene ID
- 970
- Target UniProt ID
- P32970
- Overview
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
- Overview
- Humanized Anti-CD70 lgG1 Antibody, clone # h1f6
- Clone #
- h1F6
- Species Reactivity
- Human
- Name
- β-glucuronide linker
- Description
- β-Glucuronide linkers belong to Enzymatically cleavable linkers, which have expected stability and provide facile release of the active drug. The cleavage of the β-glucuronide glycosidic bond relies on lysosomal enzyme β-glucuronidase, and this enzyme is abundantly present within lysosomes and is overexpressed in some tumor types, while the enzyme activity outside cells is low.
- Name
- CBI Minor Groove Binder
For Research Use Only. NOT FOR CLINICAL USE.
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Published Data
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| CAT# | Product Name | Linker | Payload |
| ADC-W-573 | Anti-CD70-PBD ADC-6 | maleimidocaproyl-valine-alanine | pyrrolobenzodiazepine (PBD) |
| ADC-W-487 | Anti-CD70-MCC-DM1 ADC | MCC (Maleimidomethyl cyclohexane-1-carboxylate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-451 | Anti-CD70-Mc-VC-PABC-MMAF ADC-1 | MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-954 | Anti-CD70-MC-Vc-PAB-SN38 ADC-7 | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-952 | Anti-CD70-MC-MMAF ADC-7 | MC (maleimidocaproyl) | MMAF |
| CAT# | Product Name | Linker | Payload |
| ADC-W-349 | Anti-TNFRSF8-β-glucuronide-Camptothecin Analog ADC-14 | β-glucuronide linker | Camptothecin Analog |
| ADC-W-352 | Anti-TNFRSF8-β-glucuronide-MMAF ADC-12 | β-glucuronide linker | MMAF (Monomethyl auristatin F) |
| ADC-W-372 | Anti-CD70-β-glucuronide-Camptothecin Analog ADC-5 | β-glucuronide linker | Camptothecin Analog |
| ADC-W-374 | Anti-CD70-β-glucuronide-MMAE ADC-5 | β-glucuronide linker | MMAE (Monomethyl auristatin E) |
| ADC-W-350 | Anti-TNFRSF8-β-glucuronide-CBI Minor Groove Binder ADC-14 | β-glucuronide linker | CBI Minor Groove Binder |
| CAT# | Product Name | Linker | Payload |
| ADC-W-350 | Anti-TNFRSF8-β-glucuronide-CBI Minor Groove Binder ADC-14 | β-glucuronide linker | CBI Minor Groove Binder |
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