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- Anti-CD70-Mc-VC-PBD ADC-5
Anti-CD70-Mc-VC-PBD ADC-5 (CAT#: ADC-W-446)
This ADC product is comprised of an anti-CD70 monoclonal antibody (clone h1F6) conjugated via a Mc-VC linker to PDB. The PDB is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell,PDB binds to DNA, causes DNA damage.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Antibody clone #
- h1F6
- Name
- CD70
- Alternative Names
- CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;
- Target Entrez Gene ID
- 970
- Target UniProt ID
- P32970
- Overview
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
- Overview
- Anti-CD70 Antibody, clone # H1f6
- Clone #
- h1F6
- Species Reactivity
- Human
- Name
- mc-VC (maleimidocaproyl-valine-citrulline)
- Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Name
- pyrrolobenzodiazepine (PBD) dimers
- Description
- Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.
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Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-375 | Anti-CD70-β-glucuronide-MMAF ADC-5 | β-glucuronide linker | MMAF (Monomethyl auristatin F) |
| ADC-W-451 | Anti-CD70-Mc-VC-PABC-MMAF ADC-1 | MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-954 | Anti-CD70-MC-Vc-PAB-SN38 ADC-7 | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-950 | Anti-CD70-SMCC-DM1 ADC-7 | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-951 | Anti-CD70-SPDB-DM4 ADC-7 | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-364 | Anti-CD70-Mc-VC-MMAF ADC-3 | mc-VC (maleimidocaproyl-valine-citrulline) | MMAF (Monomethyl auristatin F) |
| ADC-W-343 | Anti-TNFRSF8-Mc-VC-MMAE ADC-12 | mc-VC (maleimidocaproyl-valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-430 | Anti-PMEL-Mc-VC-MMAE ADC | mc-VC (maleimidocaproyl-valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-435 | Anti-SLITRK6-Mc-VC-MMAE ADC | mc-VC (maleimidocaproyl-valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-432 | Anti-FOLH1-Mc-VC-MMAE ADC-2 | mc-VC (maleimidocaproyl-valine-citrulline) | MMAE (Monomethyl auristatin E) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-108 | Anti-DLL3-PBD dimers ADC-6 | pyrrolobenzodiazepine (PBD) dimers | |
| ADC-W-304 | Anti-CDH1-PBD dimers ADC | pyrrolobenzodiazepine (PBD) dimers | |
| ADC-W-102 | Anti-DLL3-PBD dimers ADC-1 | pyrrolobenzodiazepine (PBD) dimers | |
| ADC-W-555 | Anti-IL2RA-PBD ADC | pyrrolobenzodiazepine (PBD) dimers | |
| ADC-W-107 | Anti-DLL3-PBD dimers ADC-5 | pyrrolobenzodiazepine (PBD) dimers |
For Research Use Only. NOT FOR CLINICAL USE.
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