- Home
- Products
- Customized ADCs
- 24P4C12
- Anti-24P4C12-VC-MMAE ADC
Anti-24P4C12-VC-MMAE ADC (CAT#: ADC-W-017)
This ADC product is comprised of an anti-24P4C12 monoclonal antibody (clone Ha5-l(5)2.1)) conjugated via a VC linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Antibody clone #
- Ha5-l(5)2.1.
- Name
- 24P4C12
- Overview
- Chimeric Anti-24P4C12 antibody, clone # Ha5-l(5)2.1.
- Clone #
- Ha5-l(5)2.1.
- Species Reactivity
- Human
- Name
- VC (valine-citrulline)
- Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Name
- MMAE (Monomethyl auristatin E)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- Anti-CD33 (Lintuzumab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-815)
- Anti-EGFR (Matuzumab)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-1038)
- Anti-MSLN (Amatuximab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-1595)
- Anti-IL22 (Fezakinumab)-SPDB-DM4 ADC (CAT#: ADC-W-1341)
- Anti-ERBB2-PEG-cycloalkyne-MMAF ADC (CAT#: ADC-W-175)
- Anti-CD19-Mc-VC-PABC-MMAE ADC-5 (CAT#: ADC-W-615)
- Anti-TNC (Tenatumomab)-SMCC-DM1 ADC (CAT#: ADC-W-1814)
- Anti-MUC5A (Ensituximab)-MC-MMAF ADC (CAT#: ADC-W-1654)
- Anti-Endotoxin (Nebacumab)-SPDB-DM4 ADC (CAT#: ADC-W-2085)
- Anti-ACVR2B (Bimagrumab)-MC-MMAF ADC (CAT#: ADC-W-652)
Published Data
+ Submit Publications
Scientific Resources
Customer Reviews and FAQs
There are currently no Customer reviews or questions for ADC-W-017. Click the button above to contact us or submit your feedback about this product.
Quick Links
Other Products
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-AA-056 | Anti-MIgG-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-565 | Anti-EDNRB-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-564 | Anti-MUC16-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-052 | Protein A-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-514 | Anti-ERBB2 (Trastuzumab)-VC-DUBA ADC | VC (valine-citrulline) | seco-DUBA (DUocarmycin hydroxyBenzamide Azaindole) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-465 | Anti-TNFRSF8 (Brentuximab)-VC-PAB-MMAE ADC | VC-PAB (valine-citrulline with PAB) | MMAE (Monomethyl auristatin E) |
| ADC-W-462 | Anti-GPNMB-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-536 | Anti-EDNRB (endothelin B)-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-565 | Anti-EDNRB-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-029 | anti-MIgG(Fc)Fab-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
Online Inquiry
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
