Anti-CD74 (clone hLL1)-SMCC-Dox ADC (ADC-W-479)

This ADC product is comprised of an anti-CD74 monoclonal antibody (clone hLL1) conjugated via a SMCC linker to DOX. The DOX is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, DOX binds to DNA, causes DNA damage.
  • Antibody clone #
  • hLL1
  • Similar to
  • milatuzumab-dox(IMMU-110)

 ADC Target

  • Name
  • CD74
  • Alternative Names
  • CD74; CD74 molecule, major histocompatibility complex, class II invariant chain; II; DHLAG; HLADG; Ia-GAMMA; HLA class II histocompatibility antigen gamma chain; p33; HLA-DR-gamma; MHC HLA-DR gamma chain; Ia-associated invariant chain; gamma chain of clas
  • Target Entrez Gene ID
  • 972
  • Overview
  • The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

 ADC Antibody

  • Overview
  • Humanized Anti-ECD74 Antibody, clone # Hll1
  • Generic name
  • milatuzumab
  • Clone #
  • hLL1
  • Species Reactivity
  • Human

 ADC Linker

  • Name
  • SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
  • Description
  • Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.

 ADC payload drug

  • Name
  • Doxorubicin
  • Description
  • Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®, which is a type of anti-cancer chemotherapy drug called an anthracycline. Doxorubicin works by blocking an enzyme called TopoisomeraseⅡthat cancer cells need to divide and grow.

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