- Home
- Products
- Customized ADCs
- CD22
- Anti-CD22-SN-38 ADC-1
Anti-CD22-SN-38 ADC-1 (CAT#: ADC-W-093)
This ADC product is comprised of an anti-CD22 monoclonal antibody conjugated (clone hLL2) via a linker to SN-38. The SN-38 is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, SN-38 binds to DNA, causes DNA damage.
- ADC Target
- ADC Antibody
- ADC payload drug
- Name
- CD22
- Alternative Names
- CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2;
- Target Entrez Gene ID
- 933
- Target UniProt ID
- P20273
- Overview
- CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases. CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.
- Overview
- Humanized Anti-CD22-antibody, hLL2
- Generic name
- hLL2
- Species Reactivity
- Human
- Name
- SN-38 (7-ethyl-10-hydroxycamptothecin)
- Description
- SN38 (7-ethyl-10-hydroxy camptothecin) is an active metabolite of the cancer prodrug, irinotecan, with the ability of inhibiting Topoisomerase I, which is belong to the camptothecin family. SN-38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1.
Published Data
+ Submit Publications
Scientific Resources
Customer Reviews and FAQs
There are currently no Customer reviews or questions for ADC-W-093. Click the button above to contact us or submit your feedback about this product.
Quick Links
Other Products
Same Target
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-2535 | Anti-CD22 (Pinatuzumab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-461 | Anti-CD22-AcBut-CalichDMH ADC-10 | AcBut (4-(4-acetylphenoxy)butanoic acid) | CalichDMH |
| ADC-W-2529 | Anti-CD22-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-2528 | Anti-CD22-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
| ADC-W-2533 | Anti-CD22 (Pinatuzumab)-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-2581 | Anti-CEACAM5-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-2575 | Anti-SLC34A2 (Lifastuzumab )-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-2624 | Anti-NCAM1 (Lorvotuzumab )-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-2596 | Anti-ERBB2 (Trastuzumab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-2593 | Anti-EGFR (Cetuximab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- Anti-IFNA1 (Sifalimumab)-SPDB-DM4 ADC (CAT#: ADC-W-2349)
- Anti-IL4R -SPDB-DM4 ADC (CAT#: ADC-W-1383)
- Anti-PVRL4 (Enfortumab vedotin)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-2400)
- Anti-IGHE (Ligelizumab)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-1284)
- Anti-ERBB2 (Trastuzumab)-vandetanib ADC (CAT#: ADC-W-513)
- Anti-MST1R (Narnatumab)-SPDB-DM4 ADC (CAT#: ADC-W-1599)
- Anti-AOC3 (Vepalimomab)-SMCC-DM1 ADC (CAT#: ADC-W-674)
- Anti-MSLN (Amatuximab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-1595)
- Anti-TDGF1-Disulfide-linker-DM4 ADC (CAT#: ADC-W-385)
- Anti-GPNMB-VC-MMAE ADC (CAT#: ADC-W-462)
Online Inquiry
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
