Anti-EFNA4 (clone huE22)-AcBut-CM ADC (ADC-W-018)

This ADC product is comprised of an anti-EFNA4 monoclonal antibody (clone huE22)) conjugated via an AcBut linker to CM. The CM is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis.
  • Antibody clone #
  • huE22

 ADC Target

  • Name
  • EFNA4
  • Alternative Names
  • ephrin-A4; EFL4; EPLG4; LERK4; LERK-4; ligand of eph-related kinase 4; eph-related receptor tyrosine kinase ligand 4;
  • Target Entrez Gene ID
  • 1945
  • Overview
  • This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified.

 ADC Antibody

  • Overview
  • Anti-EFNA4-antibody, clone # huE22
  • Clone #
  • huE22
  • Species Reactivity
  • Human

 ADC Linker

  • Name
  • AcBut [-(4' acetyl phenoxy) butanoic acid]
  • Description
  • Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.

 ADC payload drug

  • Name
  • CM (N-acetyl-y-calicheamicin dimethyl hydrazide)

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