Anti-TPBG (clone H8)-AcBut-CalichDMH ADC (ADC-W-200)

This ADC product is comprised of an anti-TPBG monoclonal antibody (clone H8) conjugated via a AcBut linker to CalichDMH. The CalichDMH is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, CalichDMH binds to DNA, causes DNA damage.
  • Antibody clone #
  • Humanized H8 Antibody

 ADC Target

  • Name
  • TPBG
  • Alternative Names
  • M6P1; TPBGAG; WAIF1; TPBG oncofetal antigen; TPBG oncotrophoblast glycoprotein; wnt-activated inhibitory factor 1; TPBG oncofetal trophoblast glycoprotein;
  • Target Entrez Gene ID
  • 7162
  • Overview
  • This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein.

 ADC Antibody

  • Overview
  • Humanized Anti-TPBG antibody, clone # Humanized H8
  • Clone #
  • Humanized H8 Antibody
  • Species Reactivity
  • Human

 ADC Linker

  • Name
  • AcBut (4-(4'acetylphenoxy)butanoic acid)
  • Description
  • Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3–7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0–6.5) and lysosomal (pH 4.5–5.0) compartments of the cell.

 ADC payload drug

  • Name
  • CalichDMH (Calicheamicin (CM))
  • Description
  • Calicheamicin,produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

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