- Home
- Products
- Customized ADCs
- CD33
- Anti-CD33-AcBut-Calicheamicin ADC-4
Anti-CD33-AcBut-Calicheamicin ADC-4 (CAT#: ADC-W-357)
This ADC product is comprised of an anti-CD33 monoclonal antibody (clone HuM195) conjugated via a AcBut linker to a Calicheamicin. The Calicheamicin is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, Calicheamicin binds to DNA, causes DNA damage.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Antibody clone #
- HuM195
- Name
- CD33
- Alternative Names
- CD33; CD33 molecule; p67; SIGLEC3; SIGLEC-3; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3;
- Target Entrez Gene ID
- 945
- Target UniProt ID
- P20138
- Overview
- CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. It binds sialic acids, therefore is a member of the SIGLEC family of lectins.
- Overview
- Humanized Anti-CD33 lgG1 Antibody, clone # HuM195
- Clone #
- HuM195
- Species Reactivity
- Human
- Name
- AcBut [-(4' acetyl phenoxy) butanoic acid]
- Description
- Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Name
- calicheamicin
- Description
- Calicheamicin,produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- Anti-EGFR (Panitumumab)-MC-MMAF ADC (CAT#: ADC-W-1042)
- Anti-CD4 (Cedelizumab)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-888)
- Anti-ITGB2 (Rovelizumab)-SPDB-DM4 ADC (CAT#: ADC-W-1503)
- Anti-ERBB2 (Trastuzumab)-VC-DUBA ADC (CAT#: ADC-W-514)
- Anti-APP (Bapineuzumab)-SPDB-DM4 ADC (CAT#: ADC-W-705)
- Anti-HGF (Ficlatuzumab)-SPDB-DM4 ADC (CAT#: ADC-W-1197)
- Anti-HBV (Exbivirumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (CAT#: ADC-W-2077)
- Anti-MS4A1 (Ibritumomab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-1553)
- Anti-IL2RA (Basiliximab)-MC-MMAF ADC (CAT#: ADC-W-1366)
- Anti-TNFRSF8 (Brentuximab )-SPDB-DM4 ADC (CAT#: ADC-W-2344)
Published Data
+ Submit Publications
Scientific Resources
Customer Reviews and FAQs
There are currently no Customer reviews or questions for ADC-W-357. Click the button above to contact us or submit your feedback about this product.
Quick Links
Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-115 | Anti-CD33-Mc-MMAF ADC-1 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-2542 | Anti-CD33 (Gemtuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
| ADC-W-464 | Anti-CD33-AcBut-Calicheamicin ADC-5 | AcBut (4-(4-acetylphenoxy)butanoic acid) | Calicheamicin |
| ADC-W-815 | Anti-CD33 (Lintuzumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-814 | Anti-CD33 (Lintuzumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| CAT# | Product Name | Linker | Payload |
| ADC-W-019 | Anti-EFNA4-AcBut-CM ADC-2 | AcBut [-(4' acetyl phenoxy) butanoic acid] | CM (N-acetyl-y-calicheamicin dimethyl hydrazide) |
| ADC-W-018 | Anti-EFNA4-AcBut-CM ADC-1 | AcBut [-(4' acetyl phenoxy) butanoic acid] | CM (N-acetyl-y-calicheamicin dimethyl hydrazide) |
| ADC-W-008 | Anti-TPBG-AcBut-calicheamicin ADC-1 | AcBut [-(4' acetyl phenoxy) butanoic acid] | calicheamicin |
| ADC-W-459 | Anti-FUT3-AcBut-CalichDMH ADC-2 | AcBut [-(4' acetyl phenoxy) butanoic acid] | CalichDMH |
| ADC-W-332 | Anti-CD22-AcBut-Calicheamicin ADC-7 | AcBut [-(4' acetyl phenoxy) butanoic acid] | calicheamicin |
| CAT# | Product Name | Linker | Payload |
| ADC-W-556 | Anti-EphA4-calicheamicin ADC | Calicheamicin | |
| ADC-W-332 | Anti-CD22-AcBut-Calicheamicin ADC-7 | AcBut [-(4' acetyl phenoxy) butanoic acid] | calicheamicin |
| WJY-0423-LS106 | Protein A-Calicheamicin ADC | Cleavable linkers | Calicheamicin |
| ADC-W-008 | Anti-TPBG-AcBut-calicheamicin ADC-1 | AcBut [-(4' acetyl phenoxy) butanoic acid] | calicheamicin |
| ADC-W-338 | Anti-CD22 (Inotuzumab)-hydrazone-Calicheamicin ADC | hydrazone | calicheamicin |
Online Inquiry
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
