Icrucumab-Alexa 350 (ADC-FL-1477)

This product is comprised of an anti-FLT1 monoclonal antibody (Icrucumab) labeled with Alexa Fluor 350. Alexa Fluor 350 is a blue-fluorescent dye and it's excitation/emission is 346/442 nm.

 TARGET

  • Name
  • FLT1
  • Alternative Names
  • FLT1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FLT; vascular endothelial growth factor receptor 1; VEGFR1; FLT-1; VEGFR-1; fms-like tyrosine kinase 1; tyrosine-protein kinase FRT; tyrosine-pties in blood due to endogenous inhibitors and the unfavorably hig
  • Overview
  • This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.

 ANTIBODY

  • Overview
  • Human Anti-FLT1 IgG1-kappa antibody, Icrucumab
  • Generic name
  • Icrucumab
  • Host animal
  • Human
  • Species Reactivity
  • Human

 DYE

  • Name
  • Alexa Fluor 350
  • Color
  • Blue
  • Excitation⁄Emission (nm)
  • 346/442
  • Detection method
  • Fluorescent

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