Anti-Dabigatran (Idarucizumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (ADC-W-2413)

 ADC Target

  • Name
  • Dabigatran
  • Alternative Names
  • Dabigatran
  • Overview
  • Dabigatran, sold under the brand name Pradaxa among others, is an anticoagulant medication which can be taken by mouth. It is used as an alternative to warfarin, since it does not have to be monitored by blood tests, but offers similar results in terms of efficacy.

 ADC Antibody

  • Overview
  • Humanized Anti-Dabigatran IgG1-Fab’ fragment, Idarucizumab
  • Generic name
  • Idarucizumab

 ADC Linker

  • Name
  • MC-Vc-PAB-DMEA-(PEG2)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

 ADC payload drug

  • Name
  • duocarmycin SA
  • Description
  • Duocarmycins SA belong to the minor-groove-binding DNA-alkylating agents (DNA MGBA). The natural duocarmycins are isolated from the culture broth of Streptmyces sp and a series of derivatives has also been synthesized.

For lab research use only, not for any in vivo human use.


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