Ipilimumab-iFluor 555 (ADC-FL-1032)

This product is comprised of an anti-CTLA4 monoclonal antibody (Ipilimumab) labeled with iFluor 555. iFluor 555 is a fluorescent dye and it's excitation/emission is 555/580 nm.

 TARGET

  • Name
  • CTLA4
  • Alternative Names
  • CTLA4; cytotoxic T-lymphocyte-associated protein 4; celiac disease 3 , CELIAC3; cytotoxic T-lymphocyte protein 4; CD; CD28; CD152; GSE; ICOS; CD152 isoform; celiac disease 3; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; GRD4; CTLA-4; IDDM12; CELIAC3;
  • Overview
  • This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

 ANTIBODY

  • Overview
  • Human Anti-CTLA4 IgG1-kappa antibody, Ipilimumab
  • Generic name
  • Ipilimumab
  • Species Reactivity
  • Human

 DYE

  • Name
  • iFluor 555
  • Excitation⁄Emission (nm)
  • 555/580
  • Detection method
  • Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.


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