Itolizumab-Coumarin (ADC-FL-877)

This product is comprised of an anti-CD6 monoclonal antibody (Itolizumab) labeled with Coumarin. Coumarin is a blue-fluorescent dye and it's excitation/emission is 387/470 nm.

 TARGET

  • Name
  • CD6
  • Alternative Names
  • CD6; CD6 molecule; CD6 antigen; T-cell differentiation antigen CD6; Tp120; T12; TP120; FLJ44171;
  • Overview
  • This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene.

 ANTIBODY

  • Overview
  • Humanized Anti-CD6 IgG1-kappa antibody, Itolizumab
  • Generic name
  • Itolizumab
  • Species Reactivity
  • Human

 DYE

  • Name
  • Coumarin
  • Color
  • Blue
  • Excitation⁄Emission (nm)
  • 387/470
  • Detection method
  • Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.


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