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Anti-MELTF (clone L49)-VC-MMAF ADC (ADC-W-453)

This ADC product is comprised of an anti-MELTF monoclonal antibody (clone L49) conjugated via a VC linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
  • Antibody clone #
  • L49

 ADC Target

  • Name
  • MELTF
  • Alternative Names
  • MFI2; antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5; MTF1; CD228; MAP97; melanotransferrin; membrane-bound transferrin-like protein; melanoma-associated antigen p97, isoform 2;
  • Target Entrez Gene ID
  • 4241
  • Overview
  • The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants.

 ADC Antibody

  • Overview
  • Anti-MELTF Antibody, clone # L49
  • Clone #
  • L49
  • Species Reactivity
  • Human

 ADC Linker

  • Name
  • VC (valine-citrulline)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

 ADC payload drug

  • Name
  • MMAF (Monomethyl auristatin F)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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