This product is comprised of an anti-CFD Fab' fragment (lampalizumab) labeled with cy5. cy5 is a far-red-fluorescent dye and it's excitation/emission is 649/666 nm.
TARGET
- Alternative Names
- CFD; complement factor D (adipsin); D component of complement (adipsin) , DF, PFD, properdin factor D; complement factor D; ADN; properdin factor D; C3 convertase activator; complement factor D preproprotein; D component of complement (adipsin); DF; PFD; ADIPSIN;
- Overview
- This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease.
ANTIBODY
- Overview
- Chimeric Anti-CFD IgG1-Fab’ fragment, lampalizumab
- Generic name
- lampalizumab
DYE
- Excitation⁄Emission (nm)
- 649/666
For Research Use Only. NOT FOR CLINICAL USE.
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