Anti-CFD (Lampalizumab)-MC-MMAF ADC (ADC-W-982)

This ADC product is comprised of an anti-CFD monoclonal antibody conjugated via a MC linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

 ADC Target

  • Name
  • CFD
  • Alternative Names
  • CFD; complement factor D (adipsin); D component of complement (adipsin) , DF, PFD, properdin factor D; complement factor D; ADN; properdin factor D; C3 convertase activator; complement factor D preproprotein; D component of complement (adipsin); DF; PFD;
  • Target Entrez Gene ID
  • 1675
  • Overview
  • This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine,ාܰɫࢸง݌ɵࣛ฾ݩɿࣽ๵ކʈटຬޣʒू໤޿ʜ।༛ߜʥআདྷ߹ʯ঩ྉࠕʹো࿁࠲˂৭࿸ࡏˌਐု࡬˖ਲၦ࢈˟੔႞ࢥ˩੷ვࣂ˳ઙᄌࣟ˼઻ᅃࣻ̆૞ᅻघ̐଀ᆲव̙ଢᇩ॒̣୅ሠ८̭୧ቘঋ̶உ኏ন̀஬዆৅͊௎ዽৡ͓௰ጵ৾͝ఓ፬ਛͧవᎣਸͰ౗Ꮪ੔ͺ౺ᐑੱ΄ಜᑉ઎΍ಾᒀફΗೡᒷેΡഃᓮ૤Ϊഥᔦଁδൈᕝଞξ൪ᖔ଺χඌᗋୗϑදᘃ୴ϛෑᘺஐϤෳᙱ஭Ϯถᚨொϸุᛠ௧Ё๛᜗ఃЋ๽ᝎఠЕຟចఽПໂួౚШ໤៴౶в༆ᠫಓм༩ᡢರхཋᢚ್я཭ᣑ೩љྐᤈആѢྲ᤿ണѬ࿔᥷ീѶ࿷᦮൜ѿမ᧥൹҉ျ᨜ඖғၞᩓඳҜႀ᪋ාҦႢ᫂෬ҰჅ᫹ฉҹყᬰฦӃᄉ᭨โӍᄬᮟ๟Ӗᅎᯖ๼ӠᅰᰍນӪᆓ᱅ີӳᆵᱼ໒ӽᇗᲳ໯ԇᇺᳪ༌Ԑሜᴢ༨ԚሾᵙཅԤቡᶐརԭኃ᷇ཾԷእ᷿ྛՁወḶྸՊዪṭ࿕ՔጌẤ࿱՞ጯỜဎէፑἓါձ፳Ὂ၈ջ᎖ᾁၤքᎸᾹႁ֎Ꮫ῰႞֘ᏽ‧Ⴛ֢ᐟ⁞თ֫ᑂₕჴֵᑤ⃍ᄑֿᒆ℄ᄮ׈ᒩ℻ᅊגᓋⅲᅧלᓭ↪ᆄץᔐ⇡ᆡׯᔲ∘ᆽ׹ᕔ≏ᇚ؂ᕷ⊇ᇷ،ᖙ⊾ሔؖᖻ⋵ሰ؟ᗞ⌬ቍةᘀ⍤ቪسᘢ⎛ኇؼᙅ⏒ኣنᙧ␉ዀِᚉ⑁ዝٙᚬ⑸ዺ٣ᛎ⒯጖٭ᛰⓦጳٶᜓ┞ፐڀ᜵╕፬

 ADC Antibody

  • Overview
  • Chimeric Anti-CFD IgG1-kappa-Fab’ fragment , Lampalizumab
  • Generic name
  • Lampalizumab
  • Host animal
  • Mouse
  • Species Reactivity
  • Human

 ADC Linker

  • Name
  • MC (maleimidocaproyl)
  • Description
  • Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

 ADC payload drug

  • Name
  • MMAF
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.


Related Products


Online Inquiry
Name:
*Phone:
*E-mail Address:
*Products or Services Interested:
Company/Institution
Project Description:









Customized FluoroAb™

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

Contact us
USA
 
 Tel:
 Fax:
 Email:
Europe
 
 Tel:
 Email:
Germany
 
 Tel:
 Email:


Inquiry

Top