Anti-HBV surface antigen (Libivirumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (ADC-W-1975)

This ADC product is comprised of an anti-HBV surface antigen monoclonal antibody conjugated via a MC-Vc-PAB-DMEA-(PEG2) linker to duocarmycin SA. The duocarmycin SA is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, duocarmycin SA binds to DNA, causes DNA damage.

 ADC Target

  • Name
  • HBV surface antigen
  • Alternative Names
  • HBV surface antigen
  • Overview
  • Hepatitis B surface antigen (HBsAg) has been the principal target for laboratory testing to identify active infection by HBV.

 ADC Antibody

  • Overview
  • Human Anti-HBV surface antigen IgG1-kappa antibody, Libivirumab
  • Generic name
  • Libivirumab
  • Host animal
  • Human

 ADC Linker

  • Name
  • MC-Vc-PAB-DMEA-(PEG2)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

 ADC payload drug

  • Name
  • duocarmycin SA
  • Description
  • Duocarmycins SA belong to the minor-groove-binding DNA-alkylating agents (DNA MGBA). The natural duocarmycins are isolated from the culture broth of Streptmyces sp and a series of derivatives has also been synthesized.

For Research Use Only. NOT FOR CLINICAL USE.


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