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- anti-MIgG(Fc)-C-DMDM ADC
anti-MIgG(Fc)-C-DMDM ADC (CAT#: ADC-AA-024)
This ADC product is comprised of an anti-mouse IgG Fc specific polyclonal antibody conjugated via a cleavable linker to DMDM. The antibody portion is a secondary antibody and the drug portion, DMDM, is a cytotoxic small molecule which binds to DNA, causes DNA damage. This product displays no obvious toxicity without a primary antibody and can be a quite efficient and economical alternative to pre-screening mouse monoclonal antibodies as ADC candidates.
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Name
- IgG Fc
- Overview
- The fragment crystallizable region (Fc region) is composed of the constant region of the two heavy chains that form the IgG molecule. The Fc region of IgG bears a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. Fc binds to various cell receptors and complement proteins thus mediating different physiological effects of antibodies, such as opsonization, antibody dependent cellular cytotoxicity (ADCC), degranulation of mast cells, basophils, eosinophils and other processes.
- Overview
- anti-mouse IgG Fc specific polyclonal IgG antibody
- Species Reactivity
- Mouse
- Name
- Cleavable linkers
- Description
- Cleavable linkers rely on the physiological stimuli, which mainly include chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers including acid-labile linkers and disulfide linkers. For acid-labile linkers, intracellular release of payloads relies on the different pH between endosomes/lysosomes and blood. The release of disulfide-linked drugs is controlled by the factors in intracellular environment. Enzymatically cleavable linkers, peptide linkers and β-glucuronide linkers, are sensitive to enzymes located in cytoplasm.
- Name
- DMDM (duocarmycin DM)
- Description
- Duocarmycins belong to the minor-groove-binding DNA-alkylating agents (DNA MGBA). The natural duocarmycins are isolated from the culture broth of Streptmyces sp and a series of derivatives has also been synthesized.
For Research Use Only. NOT FOR CLINICAL USE.
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- anti-HIgG(Fc)-C-MMAF ADC (CAT#: ADC-AA-002)
- anti-HIgG(Fc)-C-MMAE ADC (CAT#: ADC-AA-003)
- anti-RIgG(Fc)Fab-N-MMAF ADC (CAT#: ADC-AA-033)
- anti-MIgG(Fc)Fab-C-DMDM ADC (CAT#: ADC-AA-030)
- Protein A-MCC-DM1 ADC (CAT#: ADC-AA-054)
- Anti-HIgG(Fc)-C-PBD ADC (CAT#: ADC-AA-059)
- Anti-HIgG(Fc)Fab-C-DX8951 ADC (CAT#: ADC-AA-062)
Published Data
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Scientific Resources
Customer Reviews and FAQs
There are currently no Customer reviews or questions for ADC-AA-024. Click the button above to contact us or submit your feedback about this product.
Customer Reviews
FAQ
Excellent
Highly Effective and Reliable This ADC worked wonders in our pre-screening tests. Efficient, with no toxicity observed without the primary antibody. Great product!
Excellent
Excellent Performance The antibody's specificity and the DMDM component were spot on. It seamlessly integrates into our experiments with consistent results.
Excellent
Outstanding Quality I was impressed with the efficiency and minimal toxicity. It's a cost-effective alternative for our ADC screenings.
Excellent
Impressive Results The product delivered as promised. Effective DNA binding with no background interference. Very satisfied!
Excellent
Top-Notch Product High specificity and cleavable linker worked perfectly in our tests. Reduced costs significantly while maintaining quality.
Excellent
Great Value This ADC is an excellent economical choice for screening. Reliable and with no noticeable toxicity. Highly recommend!
Quick Links
Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-AA-028 | anti-MIgG(Fc)Fab-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-AA-055 | Protein A-Duocarmycin ADC | Duocarmycins | |
| ADC-AA-051 | Protein G-Duocarmycin ADC | Duocarmycins | |
| ADC-AA-026 | anti-MIgG(Fc)-N-DM1 ADC | Noncleavable linkers | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-AA-048 | Protein G-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| CAT# | Product Name | Linker | Payload |
| WJY-0423-LS106 | Protein A-Calicheamicin ADC | Cleavable linkers | Calicheamicin |
| ADC-AA-064 | Anti-HIgG(Fab)-C-MMAF ADC | Cleavable linkers | MMAF |
| ADC-AA-020 | anti-MIgG(Fc)-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-AA-017 | anti-HIgG(Fab)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-021 | anti-MIgG(Fc)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-030 | anti-MIgG(Fc)Fab-C-DMDM ADC | Cleavable linkers | DMDM (duocarmycin DM) |
| ADC-AA-013 | anti-HIgG(Fc)Fab-C-DMDM ADC | Cleavable linkers | DMDM (duocarmycin DM) |
| ADC-AA-044 | anti-Rat IgG(Fc)Fab-C-DMDM ADC | Cleavable linkers | DMDM (duocarmycin DM) |
| ADC-AA-006 | anti-HIgG(Fc)-C-DMDM ADC | Cleavable linkers | DMDM (duocarmycin DM) |
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