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- anti-MIgG(Fc)-C-DMSA ADC
anti-MIgG(Fc)-C-DMSA ADC (CAT#: ADC-AA-023)
This ADC product is comprised of an anti-mouse IgG Fc specific polyclonal antibody conjugated via a cleavable linker to DMSA. The antibody portion is a secondary antibody and the drug portion, DMSA, is a cytotoxic small molecule which binds to DNA, causes DNA damage. This product displays no obvious toxicity without a primary antibody and can be a quite efficient and economical alternative to pre-screening mouse monoclonal antibodies as ADC candidates.
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Name
- IgG Fc
- Overview
- The fragment crystallizable region (Fc region) is composed of the constant region of the two heavy chains that form the IgG molecule. The Fc region of IgG bears a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. Fc binds to various cell receptors and complement proteins thus mediating different physiological effects of antibodies, such as opsonization, antibody dependent cellular cytotoxicity (ADCC), degranulation of mast cells, basophils, eosinophils and other processes.
- Overview
- anti-mouse IgG Fc specific polyclonal IgG antibody
- Species Reactivity
- Mouse
- Name
- Cleavable linkers
- Description
- Cleavable linkers rely on the physiological stimuli, which mainly include chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers including acid-labile linkers and disulfide linkers. For acid-labile linkers, intracellular release of payloads relies on the different pH between endosomes/lysosomes and blood. The release of disulfide-linked drugs is controlled by the factors in intracellular environment. Enzymatically cleavable linkers, peptide linkers and β-glucuronide linkers, are sensitive to enzymes located in cytoplasm.
- Name
- DMSA (duocarmycin SA)
- Description
- Duocarmycins belong to the minor-groove-binding DNA-alkylating agents (DNA MGBA). The natural duocarmycins are isolated from the culture broth of Streptmyces sp and a series of derivatives has also been synthesized.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
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- Anti-MIgG(Fc)-C-PBD ADC (CAT#: ADC-AA-058)
- anti-HIgG(Fc)-C-DMDM ADC (CAT#: ADC-AA-006)
- anti-RIgG(HL)-C-MMAE ADC (CAT#: ADC-AA-036)
- anti-Rat IgG(Fc)-C-MMAF ADC (CAT#: ADC-AA-040)
- anti-HIgG(Fc)Fab-C-DMSA ADC (CAT#: ADC-AA-012)
- anti-MIgG(Fc)-C-MMAF ADC (CAT#: ADC-AA-020)
- anti-MIgG(Fc)Fab-C-DMDM ADC (CAT#: ADC-AA-030)
- Protein A-MMAF ADC (CAT#: ADC-AA-053)
Published Data
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Quick Links
Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-AA-029 | anti-MIgG(Fc)Fab-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-050 | Protein G-MCC-DM1 ADC | MCC (Maleimidomethyl cyclohexane-1-carboxylate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-AA-051 | Protein G-Duocarmycin ADC | Duocarmycins | |
| ADC-AA-049 | Protein G-MMAF ADC | MMAF (Monomethyl auristatin F) | |
| ADC-AA-052 | Protein A-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-003 | anti-HIgG(Fc)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-017 | anti-HIgG(Fab)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-011 | anti-HIgG(Fc)Fab-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| WJY-0423-LS106 | Protein A-Calicheamicin ADC | Cleavable linkers | Calicheamicin |
| WJY-0423-LS107 | Protein A-PBD ADC | Cleavable linkers | PBD (pyrrolobenzodiazepine) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-005 | anti-HIgG(Fc)-C-DMSA ADC | Cleavable linkers | DMSA (duocarmycin SA) |
| ADC-AA-012 | anti-HIgG(Fc)Fab-C-DMSA ADC | Cleavable linkers | DMSA (duocarmycin SA) |
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