Anti-ROR1 scFv-Fc-Sec ADC (CAT#: ADC-W-434)

Name: Anti-ROR1 scFv-Fc-Sec ADC
SKU: ADC-W-434
Rating: 5 (1 reviews)

This ADC product is comprised of an anti-ROR1 scFv-Fc (clone R11) conjugated via a engineered selenocysteine (Sec) residue linker to a drug.

Alternative Names
ROR1; receptor tyrosine kinase-like orphan receptor 1; NTRKR1; dJ537F10.1; tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase, receptor-related 1;

Overview
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.