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  5. Anti-Rabies Virus Glycoprotein (Rafivirumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC

Anti-Rabies Virus Glycoprotein (Rafivirumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (ADC-W-1963)

This ADC product is comprised of an anti-Rabies Virus Glycoprotein monoclonal antibody conjugated via a MC-Vc-PAB-DMEA-(PEG2) linker to duocarmycin SA. The duocarmycin SA is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, duocarmycin SA binds to DNA, causes DNA damage.

 ADC Target

  • Name
  • Rabies Virus Glycoprotein
  • Alternative Names
  • Rabies Virus Glycoprotein
  • Overview
  • This peptide is a 29 amino acid fragment derived from rabies virus glycoprotein (RVG). Because neurotropic viruses cross the blood-brain barrier to infect brain cells, the same strategy may be used to enter the central nervous system and deliver siRNA to the brain. This peptide specifically binds to the acetylcholine receptor expressed by neuronal cells.

 ADC Antibody

  • Overview
  • Human Anti-Rabies Virus Glycoprotein IgG1-lambda antibody, Rafivirumab
  • Generic name
  • Rafivirumab
  • Host animal
  • Human

 ADC Linker

  • Name
  • MC-Vc-PAB-DMEA-(PEG2)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

 ADC payload drug

  • Name
  • duocarmycin SA
  • Description
  • Duocarmycins SA belong to the minor-groove-binding DNA-alkylating agents (DNA MGBA). The natural duocarmycins are isolated from the culture broth of Streptmyces sp and a series of derivatives has also been synthesized.

For Research Use Only. NOT FOR CLINICAL USE.

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