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- anti-Rat IgG(HL)Fab-C-MMAF ADC
anti-Rat IgG(HL)Fab-C-MMAF ADC (CAT#: ADC-AA-047)
This ADC product is comprised of a Fab fragment of an anti-rat IgG(H+L) specific polyclonal antibody conjugated via a cleavable linker to MMAF. The antibody portion is a Fab fragment of a secondary antibody and the drug portion, MMAF, is a cytotoxic small molecule which binds to tubulins, interrupts microtubule dynamics, and induces cell death. This product displays no obvious toxicity without a primary antibody and can be a quite efficient and economical alternative to pre-screening rat monoclonal antibodies as ADC candidates.
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Name
- IgG(H+L)
- Overview
- IgG antibody subtype is the most abundant serum immunoglobulins of the immune system, which is a protein complex composed of four peptide chains—two identical heavy chains and two identical light chains arranged in a Y-shape typical of antibody monomers. IgG is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses.
- Overview
- Fab fragment of anti-rat IgG(H+L) specific polyclonal IgG antibody
- Species Reactivity
- Rat
- Name
- Cleavable linkers
- Description
- Cleavable linkers rely on the physiological stimuli, which mainly include chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers including acid-labile linkers and disulfide linkers. For acid-labile linkers, intracellular release of payloads relies on the different pH between endosomes/lysosomes and blood. The release of disulfide-linked drugs is controlled by the factors in intracellular environment. Enzymatically cleavable linkers, peptide linkers and β-glucuronide linkers, are sensitive to enzymes located in cytoplasm.
- Name
- MMAF (Monomethyl auristatin F)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
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Published Data
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Scientific Resources
Customer Reviews and FAQs
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Customer Reviews
FAQ
Excellent
We've been using the anti-Rat IgG(HL)Fab-C-MMAF ADC for targeted cytotoxicity studies, and it has consistently shown excellent performance in inducing cell death without general toxicity.
Excellent
This ADC has proven to be a cost-effective solution for our needs, providing reliable results in pre-screening rat antibodies with high specificity and reduced risk of toxicity.
Excellent
I'm impressed by the anti-Rat IgG(HL)Fab-C-MMAF ADC's ability to bind specifically to tubulins and disrupt microtubule dynamics effectively, facilitating our research into cellular mechanisms.
Excellent
Using the anti-Rat IgG(HL)Fab-C-MMAF ADC has streamlined our screening process for therapeutic antibodies in rats. Its efficiency and economic value are unmatched.
Excellent
The specificity of the anti-Rat IgG(HL)Fab-C-MMAF ADC in targeting and eliminating diseased cells in our models has been critical to our studies' success, allowing for more focused and safer therapeutic developments.
Excellent
Creative Biolabs' ADC product has become a cornerstone of our experimental toolkit, offering precise targeting and potent cytotoxicity, which is essential for our ongoing research into immune system interactions and antibody responses.
Quick Links
Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-AA-035 | anti-RIgG(HL)-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-AA-038 | anti-RIgG(HL)Fab-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-AA-037 | anti-RIgG(HL)Fab-N-MMAF ADC | Noncleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-AA-046 | anti-Rat IgG(HL)Fab-N-MMAF ADC | Noncleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-AA-066 | Anti-Rat IgG(H+L)-C-PBD ADC | Cleavable linkers | PBD (pyrrolobenzodiazepine) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-020 | anti-MIgG(Fc)-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-AA-066 | Anti-Rat IgG(H+L)-C-PBD ADC | Cleavable linkers | PBD (pyrrolobenzodiazepine) |
| ADC-AA-002 | anti-HIgG(Fc)-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-AA-029 | anti-MIgG(Fc)Fab-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-062 | Anti-HIgG(Fc)Fab-C-DX8951 ADC | Cleavable linkers | DX8953 |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-019 | anti-MIgG(Fc)-N-MMAF ADC | Noncleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-W-515 | Anti-EGFR-Mc-MMAF ADC-5 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-AA-009 | anti-HIgG(Fc)Fab-N-MMAF ADC | Noncleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-W-493 | Anti-CD19-Mc-MMAF ADC-3 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-AA-010 | anti-HIgG(Fc)Fab-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
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