Rilotumumab-Alexa 350 (ADC-FL-1585)

This product is comprised of an anti-HGF monoclonal antibody (Rilotumumab) labeled with Alexa Fluor 350. Alexa Fluor 350 is a blue-fluorescent dye and it's excitation/emission is 346/442 nm.

 TARGET

  • Name
  • HGF
  • Alternative Names
  • HGF; hepatocyte growth factor (hepapoietin A; scatter factor); deafness, autosomal recessive 39 , DFNB39; hepatocyte growth factor; F TCF; fibroblast derived tumor cytotoxic factor; hepatopoietin A; HGFB; HPTA; lung fibroblast derived mitogen;
  • Overview
  • This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss.

 ANTIBODY

  • Overview
  • Human Anti-HGF IgG2-kappa antibody, Rilotumumab
  • Generic name
  • Rilotumumab
  • Host animal
  • Human
  • Species Reactivity
  • Human

 DYE

  • Name
  • Alexa Fluor 350
  • Color
  • Blue
  • Excitation⁄Emission (nm)
  • 346/442
  • Detection method
  • Fluorescent

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