Sibrotuzumab-iFluor 350 (ADC-FL-1423)

This product is comprised of an anti-FAP monoclonal antibody (Sibrotuzumab) labeled with iFluor 350. iFluor 350 is a blue-fluorescent dye and it's excitation/emission is 346/442 nm.

TARGET

Name
FAP

Alternative Names
FAP; fibroblast activation protein, alpha; seprase; DPPIV; integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase; FAPA; DKFZp686G13158;

Overview
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

ANTIBODY

Overview
Humanized Anti-FAP IgG1-kappa antibody, Sibrotuzumab

Generic name
Sibrotuzumab

Species Reactivity
Human

DYE

Name
iFluor 350

Color
Blue

Excitation⁄Emission (nm)
346/442

Detection method
Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.

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