Sibrotuzumab-Alexa 350 (ADC-FL-1423)

This product is comprised of an anti-FAP monoclonal antibody (Sibrotuzumab) labeled with Alexa Fluor 350. Alexa Fluor 350 is a blue-fluorescent dye and it's excitation/emission is 346/442 nm.

 TARGET

  • Name
  • FAP
  • Alternative Names
  • FAP; fibroblast activation protein, alpha; seprase; DPPIV; integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase; FAPA; DKFZp686G13158;
  • Overview
  • The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

 ANTIBODY

  • Overview
  • Humanized Anti-FAP IgG1-kappa antibody, Sibrotuzumab
  • Generic name
  • Sibrotuzumab
  • Host animal
  • Mouse
  • Species Reactivity
  • Human

 DYE

  • Name
  • Alexa Fluor 350
  • Color
  • Blue
  • Excitation⁄Emission (nm)
  • 346/442
  • Detection method
  • Fluorescent

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