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CD33

CD33 is a lectin (sialic acid binding Ig-like lectin 3) expressed mainly on cells of myeloid lineage and on some lymphoid cells. It is also known by acronyms such as p67, SIGLEC3, or SIGLEC-3. CD33 contains two immunoglobulin domains within its extracellular portion, one Ig-like C2 type domain and one Ig-like V type domain, respectively, and two immunoreceptor tyrosine-based inhibitor motifs (ITIM) in its cytoplasmic portion.

CD33 is speculated as an adhesion molecule of the myelomonocytic-derived cells and it has been proposed to participate in mediating sialic-acid dependent interactions, during which it shows high preference towards alpha-2,6-linked sialic acid. Upon ligand binding, CD33 exerts an action mode as an inhibitory receptor that blocks signal transduction and inhibits downstream cellular activities during immune responses.

Entrez Gene ID: 945
UniProt ID: P20138