CD44

CD44 is a cell-surface glycoprotein which involves in cell-cell interactions, cell adhesion and migration. CD44 acts as a receptor for hyaluronic acid (HA). It can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 is reported to be associated with a broad range of cellular functions. These functions include lymphocyte activation, tumor metastasis and homing, hematopoiesis and recirculation.

Transcripts for CD44 undergo complex alternative splicing that results in many functionally distinct isoforms. However, the full-length nature of some of these variants has not been determined. Alternative splicing plays an important role in the structural and functional diversity of CD44. It is postulated to be linked with tumor metastasis. It is an essential mechanism that generates protein diversity in mammals. Alternative splicing of CD44 gives rise to two groups of protein isoforms. It is worth noting that the CD44v isoforms contain at least one of its nine variable exons. The CD44s isoform is devoid of all variable exons. CD44s and CD44v are associated with distinct signaling activation. Although CD44v augments MAPK signaling and promotes cell proliferation, CD44s stimulates PI3K/Akt activation and renders tumor cells insensitive to drug-induced cell death.
Entrez Gene ID: 960
UniProt ID: P16070

If you can’t find your product on this list? Please directly send email to

For Research Use Only. NOT FOR CLINICAL USE.


Online Inquiry
Name:
*Phone:
*E-mail Address:
*Products or Services Interested:
Company/Institution
Project Description:









Customized FluoroAb™

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

Contact us
USA
 
 Tel:
 Fax:
 Email:
Europe
 
 Tel:
 Email:
Germany
 
 Tel:
 Email:


Inquiry

Top