CEACAM6

Carcinoembryonic antigen related cell adhesion molecule 6 (CEACAM6), also known as CEAL, nonspecific cross‑reacting antigen (NCA) or Cluster of Differentiation 66c (CD66c), is a glycosyl phosphatidyl inositol (GPI)-linked membrane protein that belongs to the carcinoembryonic antigen (CEA) family within the immunoglobulin superfamily. Members of CEA family functions in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma.

Human CEACAM-6 is a 90 kDa protein that consists of a 34 amino acid (aa) signal sequence, a 286 aa extracellular domain (ECD), and a 24 aa hydrophobic C-terminal propeptide. Expression of CEACAM6 protein has been found in a variety of normal human tissues, including myeloid cells and its over-expression confers resistance to adhesion-related apoptosis (anoikis) in tumor cells. Moreover, this protein can serve as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease.

Entrez Gene ID: 4680
UniProt ID: P40199

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