CXCR4

C-X-C motif chemokine receptor 4 (CXCR4), also known as CD184, FB22, HM89, LAP3, LCR1, NPYR, WHIM or D2S201E, is a G-protein-linked seven transmembrane CXC chemokine receptor specific for stromal cell-derived factor-1 (SDF-1). As the receptor for SDF-1, CXCR4 can transduce a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. CXCR4 can also functions as a receptor for extracellular ubiquitin, which is involved in hematopoiesis, cardiac ventricular septum formation as well as the vascularization of the gastrointestinal tract. What's more, CXCR4 is one of several chemokine receptors that HIV can use to infect CD4+ T cells.

It is demonstrated that the CXCR4's expression is low or absent in many healthy tissues and it is highly expressed in more than 23 types of cancers, including breast cancer, ovarian cancer, melanoma, prostate cancer and so on. Mutations in CXCR4 gene can result in WHIM syndrome, an immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV) infection.

Gene ID: 7852
UniProt ID: P61073