SELP

Selectin P (SELP), also known as CD62 or GRMP, encoded by SELP gene, is a calcium-dependent receptor that presents in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. It can bind to its ligand-1, P-selectin glycoprotein ligand-1 (PSGL-1), on neutrophils, inducing the intracellular calcium flux-signaling. Cytosolic calcium, as a most ubiquitous second messenger, involves various intracellular signaling related to multiple cellular functions. The calcium signaling release can induce cell activation, trigger superoxide generation, regulate circulating neutrophils rolling and adhesion. In addition, during platelet activation and degranulation, the SELP can redistribute the plasma membrane and control the interaction of activated endothelial cells or platelets with leukocytes.
The SELP is widely expressed in multiple human tissues, including urinary bladder, appendix, gallbladder, lung, lymph node, prostate and 16 other tissues. A number of studies have been shown that SELP is associated with the progression of the various cardiovascular diseases, such as coronary artery disease, type 2 diabetics, atherogenesis, primary aldosteronism. These suggest that SELP can be considered as a therapeutic target to apply to treat the cardiovascular diseases.
Gene ID: 6403
UniProt ID: P16109