SLC3A2

Solute carrier family 3 member 2(SLC3A2), also known as 4F2, CD98, MDU1, 4F2HC, 4T2HC, NACAE or CD98HC, is a cell surface, transmembrane protein that belongs to the solute carrier family. This protein contains an 85 kDa glycosylated type II transmembrane heavy chain and a 40‑50 kDa non-glycosylated light chain with 12 transmembrane segments. The extracellular region of human CD98 heavy chain shares about 71% and 73% amino acid sequence identity with rat and mouse CD98 heavy chain, respectively. This protein is a widely expressed disulfide-linked heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains and it plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Moreover, this protein is also reported to be involved in integrin-dependent signaling related to normal cell growth and tumorigenesis, T cell costimulation, B cell proliferation and viral fusion with cell membranes.

Entrez Gene ID: 6520
UniProt ID: P08195