TDGF1

Teratocarcinoma-derived growth factor 1 (TDGF1), also known as CR, CRGF or CRIPTO, is an epidermal growth factor-related protein that belongs to the epidermal growth factor-CriptoFRL1Cryptic (EGF-CFC) family. All members in EGF-CFC family are signaling proteins that play an important role in cancer and various developmental processes, including the differentiation of heart muscle, formation of the germ layers and dorsal organizer, specification of anterior-posterior and left-right axes

TDGF-1 gene was originally isolated from an undifferentiated human teratocarcinoma cell line as a potential oncogene and the encoded protein is found to be involved in embryonic development and tumor growth. It is demonstrated that mutations in this gene are associated with forebrain defects. Moreover, due to its overexpression in many types of cancers and acting as a growth factor for tumors, TGDF-1 has attracted numerous researchers to use it as the target for tumor-specific immune therapy.

Gene ID: 6997
UniProt ID: P13385