TFPI

TFPI, abbreviated for tissue factor pathway inhibitor, encodes a Kunitz-type serine protease inhibitor that plays an important role in the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition or silencing of TFPI restores hemostasis in animal models of hemophilia. It's worth noting that TFPI gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization.
Two major isoforms of TFPI, resulting from an alternative splicing event, have now been described in both mice and humans: TFPIαand TFPIβ. TFPIαcontains 3 Kunitz-type inhibitory domains:K1, K2, K3 and a positively charged C terminus. TFPIβ,on the other hand, contains the K1 and K2 domains of TFPIα, followed by a unique C terminus encoding for the addition of a glycosylphosphatidylinositol (GPI) anchor. The K1 and K2 domains bind and inhibit FVIIa and FXa, respectively, whereas the K3 domain has no known inhibitory function.

Entrez Gene ID: 7035
UniProt ID: P10646

If you can’t find your product on this list? Please directly send email to

For Research Use Only. NOT FOR CLINICAL USE.


Online Inquiry
Name:
*Phone:
*E-mail Address:
*Products or Services Interested:
Company/Institution
Project Description:









Customized FluoroAb™

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

Contact us
USA
 
 Tel:
 Fax:
 Email:
Europe
 
 Tel:
 Email:
Germany
 
 Tel:
 Email:


Inquiry

Top