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Anti-FUT4 (Technetium (99mTc) fanolesomab)-MC-MMAF ADC (CAT#: ADC-W-1174)

This ADC product is comprised of an anti-FUT4 monoclonal antibody conjugated via a MC linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Name
  • FUT4
  • Alternative Names
  • FUT4; fucosyltransferase 4 (alpha (1, 3) fucosyltransferase, myeloid-specific); CD15, ELFT, FCT3A; alpha-(1, 3)-fucosyltransferase; ELAM ligand fucosyltransferase; FUC TIV; galactoside 3 L fucosyltransferase; Lewis X; fucT-IV; fucosyltransferase IV; ELAM-ndocytosis. Within the cell, duocarmycin SA binds to DNA, causes DNA damage.
  • Target Entrez Gene ID
  • 2526
  • Overview
  • The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15).
  • Overview
  • Humanized Anti-FUT4 IgM antibody, Technetium (99mTc) fanolesomab
  • Generic name
  • Technetium (99mTc) fanolesomab
  • Host animal
  • Mouse
  • Name
  • MC (maleimidocaproyl)
  • Description
  • Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Name
  • MMAF
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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ADC-W-1177 Anti-FUT4 (Technetium (99mTc) fanolesomab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA
ADC-W-2458 Anti-FUT4 (Fanolesomab)-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-2460 Anti-FUT4 (Fanolesomab)-MC-Vc-PAB-SN38 ADC MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin)
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