Toralizumab-Bodipy FL (ADC-FL-804)

This product is comprised of an anti-CD40LG monoclonal antibody (Toralizumab) labeled with Bodipy FL. Bodipy FL is a green-fluorescent dye and it's excitation/emission is 503/512 nm.

 TARGET

  • Name
  • CD40LG
  • Alternative Names
  • CD40LG; CD40 ligand; HIGM1, IMD3, TNFSF5, tumor necrosis factor (ligand) superfamily, member 5 (hyper IgM syndrome); CD40 antigen ligand; CD40L; CD154; gp39; hCD40L; hyper IgM syndrome; T B cell activating molecule; TNF related activation protein; TRAP; tnternalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
  • Overview
  • The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.

 ANTIBODY

  • Overview
  • Humanized Anti-CD40L IgG1-kappa antibody, Toralizumab
  • Generic name
  • Toralizumab
  • Species Reactivity
  • Human

 DYE

  • Name
  • Bodipy FL
  • Color
  • Green
  • Excitation⁄Emission (nm)
  • 503/512
  • Detection method
  • Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.


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