Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adhesion G protein-coupled receptor A3 |
| Gene Name | ADGRA3 |
| Uniprot | Q8IWK6 (Human); Q7TT36 (Mouse) |
| Synonym | PGR21; TEM5L; GPR125; G-protein coupled receptor 125; probable G-protein coupled receptor 125 |
| Background | ADGRA3, also known as adhesion G protein-coupled receptor A3 or G-protein coupled receptor 125 (GPR125), is a protein that encoded by the human GPR125 gene. As a member of the adhesion G protein-coupled receptor family, ADGRA3 has a long extracellular subunit with protein-protein interacting domains and a GPCR subunit. The last four amino acids (ETTV) of Gpr125 constitute a PDZ-binding motif, which is also found in the transmembrane PCP pathway components Frizzled and Vangl2. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX321 | NativeExtract™ Human ADGRA3 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| Please for more products or customization | ||||
Z***yr: Correctly folded with intact post-translational modifications, ideal for cell-based and in vitro studies.
03/Mar/2023
Q***n: Seamless technical support streamlined our GPCR research workflow.
20/Jan/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Precision Viral Vector Delivery for ADGRA3 Modulation
Creative Biolabs offers precision viral vector delivery services for ADGRA3 modulation. Viral vector systems, such as adeno-associated viruses (AAVs), enable tissue-specific delivery of therapeutic constructs to modulate ADGRA3 expression. Creative Biolabs' expertise in engineering capsid variants allows for selective targeting of ADGRA3-enriched tissues, such as tumor microenvironments or inflammatory niches. For instance, preclinical studies utilizing AAV9-derived vectors demonstrate efficient transduction of ADGRA3-overexpressing glioblastoma cells, enabling localized delivery of antisense oligonucleotides (ASOs) to suppress oncogenic signaling. This approach minimizes off-target effects while maximizing therapeutic precision—a critical advantage for oncology-focused gene therapies.
Genome-Editing Approaches for ADGRA3 Modulation
Creative Biolabs offers genome-editing services. Gene editing and base-editing platforms offer robust tools to correct or disrupt ADGRA3-associated pathogenic variants. Creative Biolabs' libraries streamline the identification of high-efficiency guide RNAs targeting ADGRA3's exon-intron boundaries, as demonstrated in models of autoimmune disorders where ADGRA3 knockdown restored immune homeostasis. Additionally, prime-editing strategies enable precise correction of single-nucleotide polymorphisms (SNPs) within ADGRA3's ligand-binding domain, a method validated in vitro to rescue dysregulated adhesion signaling in fibrotic tissues. These technologies underscore the potential for curative interventions in diseases driven by ADGRA3 dysregulation.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADGRA3 cell therapy. Please for more services.
CAR Constructs for ADGRA3-Positive Malignancies
Creative Biolabs offers CAR constructs services. ADGRA3's unique extracellular epitopes make it an ideal target for CAR-T cell therapies. Creative Biolabs' proprietary antigen-binding domain libraries have yielded CAR constructs with nanomolar affinity for ADGRA3, as evidenced by in vivo elimination of triple-negative breast cancer xenografts. Further refinements, such as hypoxia-inducible CAR activation, enhance specificity for ADGRA3-rich tumor cores while sparing healthy tissues.
Engineered Stem Cell Platforms for ADGRA3 Microenvironment Reprogramming
Creative Biolabs offers ADGRA3 microenvironment reprogramming services. Mesenchymal stem cells (MSCs) engineered to secrete ADGRA3-neutralizing biologics offer a dual mechanism: homing to disease sites and paracrine modulation of pathological signaling. Creative Biolabs' lentiviral transduction protocols enable stable expression of ADGRA3-targeting antibodies in MSCs, a strategy shown to suppress metastatic colonization in preclinical models by disrupting tumor-stroma interactions. This platform's adaptability extends to chronic inflammatory conditions, where engineered MSCs degrade ADGRA3-dependent extracellular matrix remodeling in fibrotic lungs.
The complexity of ADGRA3's pleiotropic roles demands tailored therapeutic strategies. Creative Biolabs' multidisciplinary team provides comprehensive support throughout the vector design, genome-editing optimization, and functional validation process, each step informed by decades of translational expertise. Creative Biolabs' integrated suite of gene and cell therapy solutions ensures your target transitions from concept to clinic with scientific rigor. to leverage proprietary datasets, including ADGRA3 expression profiles across 20+ disease models and functional genomic screens identifying critical synthetic lethal partners.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
