Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adhesion G protein-coupled receptor B2 |
| Gene Name | ADGRB2 |
| Uniprot | O60241 (Human); Q8CGM1 (Mouse) |
| Synonym | BAI2; brain-specific angiogenesis inhibitor 2 |
| Background | ADGRB2, also known as adhesion G protein-coupled receptor B2 or brain-specific angiogenesis inhibitor 2 (BAI2), is a protein encoded by the human BAI2 gene. It is one of three ADGRB sub-family receptors, which are also known as Brain-specific Angiogenesis Inhibitors 1-3 (BAI1-3). Studies have shown that BAI2 has a long N-terminal extracellular region (ECR) containing a GPCR proteolysis site (GPS) adjacent to the seven transmembrane (7TM) domain. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX319 | NativeExtract™ Human ADGRB2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX0018K | MemDX™ Membrane Protein Human ADGRB2 Expressed in HEK293 for Antibody Discovery, Partial (21-911aa) | HEK293 cells | Partial | N/A |
| Please for more products or customization | ||||
At***us: Received tailored ADGRB2 extracellular domain (ECD) with precise glycosylation patterns within 5 weeks.
13/Oct/2023
Fin***an: A responsive technical team enabled seamless integration with our SPR platform.
26/Jun/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
ADGRB2 Gene Editing
Creative Biolabs offers genome editing services. ADGRB2, an adhesion G protein-coupled receptor implicated in angiogenesis and synaptic plasticity, presents a compelling target for genome editing. By designing single-guide RNAs complementary to ADGRB2 promoter or coding regions it enables precise knockout or knock-in modifications to modulate receptor function. Creative Biolabs' proprietary design platform optimizes on-target specificity, minimizing off-site effects—a critical consideration for clinical translation. Our tailored libraries enable systematic screening of ADGRB2 regulatory elements, empowering researchers to identify novel therapeutic targets.
AAV Vector-Mediated ADGRB2 Overexpression
Creative Biolabs offers AAV vector-mediated ADGRB2 overexpression services. Adeno-associated virus (AAV) vectors provide a robust platform for tissue-specific ADGRB2 overexpression. Utilizing liver- or neuron-tropic AAV serotypes, researchers can deliver ADGRB2 cDNA to restore receptor expression in pathologies characterized by its deficiency. For instance, in murine models of ischemic stroke, AAV9-mediated ADGRB2 overexpression in peri-infarct neurons enhanced axonal sprouting and functional recovery. Creative Biolabs' custom AAV capsid engineering services ensure optimal biodistribution and transduction efficiency, while our validated ADGRB2 expression cassettes reduce preclinical development timelines.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADGRB2 cell therapy. Please for more services.
CAR-T Cell Engineering for ADGRB2-Positive Tumors
Creative Biolabs offers CAR-T cell engineering services. Chimeric antigen receptor (CAR)-T cells targeting ADGRB2-expressing malignancies offer a novel immunotherapeutic avenue. By engineering T cells with ADGRB2-specific extracellular domains, cytotoxic activity can be directed against tumor cells overexpressing this receptor. In a pilot study, ADGRB2-CAR-T cells exhibited potent anti-tumor responses in triple-negative breast cancer xenografts, inducing sustained regression without off-tumor toxicity. Creative Biolabs' lentiviral vector systems streamline CAR construct delivery, while our in vitro functional assays validate target specificity and efficacy, de-risking early-stage development.
ADGRB2-Modified MSCs for Tissue Regeneration
Creative Biolabs offers ADGRB2-modulated MSC services for tissue regeneration. MSCs engineered to overexpress ADGRB2 demonstrate enhanced pro-angiogenic and neuroprotective capacities. In rodent models of myocardial infarction, intra-myocardial injection of ADGRB2-modified MSCs improved cardiac function by stimulating endogenous endothelial cell proliferation. Creative Biolabs' lentiviral transduction protocols achieve >90% ADGRB2 expression rates in MSCs, and our comprehensive QC assays ensure genomic stability and phenotypic fidelity. For investigators exploring ADGRB2-driven regenerative therapies, our team provides end-to-end support, from vector design to preclinical validation.
ADGRB2's multifaceted role in disease pathophysiology positions it as a high-value therapeutic target. Creative Biolabs' integrated platforms and scientific expertise ensure your project's success. Please feel free to to discuss how our ADGRB2-focused gene and cell therapy services can streamline your pipeline, from target validation to IND-enabling studies. Let us partner with you to translate ADGRB2's potential into clinical breakthroughs.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
