Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adhesion G protein-coupled receptor B3 |
| Gene Name | ADGRB3 |
| Uniprot | O60242 (Human); Q80ZF8 (Mouse) |
| Synonym | BAI3; brain-specific angiogenesis inhibitor 3; dJ91B17.1 |
| Background | ADGRB3, also known as adhesion G protein-coupled receptor B3 or brain-specific angiogenesis inhibitor 3 (BAI3), is a protein encoded by the human BAI3 gene with a molecule weight of 200 kDa. As an orphan adhesion G protein-coupled receptor, BAI3 has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain. It has been reported that ADGRB3 has a high affinity for C1q proteins. And, C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX318 | NativeExtract™ Human ADGRB3 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX0019K | MemDX™ Membrane Protein Human ADGRB3 Expressed in HEK293 for Antibody Discovery, Partial (25-880aa) | HEK293 cells | Partial | N/A |
| Please for more products or customization | ||||
Ly****er: Creative Biolabs' ADGRB3 is ideal for high-throughput screening and structural studies.
25/Sep/2023
Z**e: Custom modifications (His-tag, buffer optimization) met exact specifications. The exceptional support team ensured seamless project integration.
03/Feb/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Genome Editing for ADGRB3 Modulation
Creative Biolabs offers genome editing services. ADGRB3, a member of the adhesion G protein-coupled receptor family, represents a compelling therapeutic target for neurodevelopmental and oncological disorders. Genomic editing enables precise inactivation or correction of ADGRB3 mutations. For example, allelic-specific knockout in preclinical glioblastoma models has demonstrated attenuated tumor proliferation by disrupting ADGRB3-mediated pro-survival signaling pathways. Creative Biolabs' optimized RNA design pipelines ensure high on-target efficiency, minimizing off-target effects—a critical consideration for clinical translation.
AAV-Mediated ADGRB3 Overexpression for Neuronal Rescue
Creative Biolabs offers AAV-mediated ADGRB3 overexpression services. Adeno-associated virus (AAV) vectors engineered with cell-specific promoters allow spatial overexpression of wild-type ADGRB3 in disease-relevant tissues. In murine models of synaptic dysfunction, AAV9-driven ADGRB3 delivery to hippocampal neurons restored dendritic spine density and synaptic plasticity. Creative Biolabs' proprietary AAV capsid library facilitates tailored tropism for CNS or peripheral tissue targeting, enhancing therapeutic precision.
ASO Strategies for Splice Variant Modulation
Creative Biolabs offers ASO development services. Pathogenic ADGRB3 splice variants contribute to aberrant signaling in neuropsychiatric disorders. ASOs designed to block cryptic splice sites can restore canonical isoform expression. In vitro studies utilizing patient-derived neuronal progenitor cells revealed normalized calcium flux post-ASO treatment. Creative Biolabs' high-throughput splice variant profiling accelerates the identification of targetable sequences, streamlining ASO development.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADGRB3 cell therapy. Please for more services.
CAR-T Cell Engineering with ADGRB3-Specific Chimeric Antigens
Creative Biolabs offers CAR-T cell engineering services. ADGRB3's ectodomain expression in select malignancies positions it as a viable target for chimeric antigen receptor (CAR)-T cell therapies. CAR constructs incorporating ADGRB3-binding scFv domains have shown potent cytotoxicity against ADGRB3+ leukemia cell lines, with minimal off-tumor reactivity in co-culture assays. Creative Biolabs' CAR-T optimization platform integrates single-cell transcriptomics to refine activation thresholds, mitigating cytokine release syndrome risks.
iPSC-Derived ADGRB3-Expressing Astrocytes
Creative Biolabs offers iPSC-derived ADGRB3-expressing astrocytes development services. iPSCs differentiated into ADGRB3-overexpressing astrocytes offer a regenerative approach for neurodegenerative diseases. Transplantation of these cells into rodent models of cortical injury enhanced neurite outgrowth and reduced glial scarring. Creative Biolabs' iPSC lines enable seamless integration of ADGRB3 transgenes under inducible promoters, ensuring temporal control over therapeutic effects.
Lentiviral Vector-Driven ADGRB3 Knockdown in Tumor-Infiltrating Lymphocytes
Creative Biolabs offers ADGRB3 Knockdown services. Lentiviral delivery of shRNA targeting ADGRB3 in tumor-infiltrating lymphocytes (TILs) disrupts immunosuppressive pathways within the tumor microenvironment. In syngeneic melanoma models, ADGRB3-silenced TILs exhibited enhanced cytotoxic activity and prolonged survival outcomes. Creative Biolabs' lentiviral packaging services guarantee high-titer, replication-incompetent vectors, critical for translational safety.
The complexity of ADGRB3 signaling demands tailored strategies to exploit its therapeutic potential. Creative Biolabs' expertise in genome editing, viral vector engineering, and cell therapy optimization provides an unparalleled foundation for accelerating your ADGRB3-focused programs. Please feel free to to explore customized solutions for target validation, delivery system design, or preclinical efficacy testing. Leverage our two decades of innovation to transform ADGRB3 biology into clinical breakthroughs.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
