Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
| Protein Name | Adhesion G protein-coupled receptor E1 |
| Gene Name | ADGRE1 |
| Uniprot | Q14246 (Human); Q61549 (Mouse) |
| Synonym | EMR1; TM7LN3; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; egf-like module containing, mucin-like, hormone receptor-like 1; egf-like module containing, mucin-like, hormone receptor-like sequence 1 |
| Background | ADGRE1, also known as EGF-like module receptor 1 (EMR1) or EGF-like module-containing mucin-like hormone receptor-like 1, is a protein encoded by the ADGRE1 gene. As a member of the adhesion GPCR family, ADGRE1 has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. And the N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX429 | NativeExtract™ Human ADGRD1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| S01YF-0423-KX307 | MemDX™ Membrane Protein Human ADGRE1 (21-599aa) Expressed in HEK293, C-6×His tag | HEK293 cells | Partial | N/A |
| Please for more products or customization | ||||
L**a: The ADGRE1 protein streamlines our adhesion assay workflows, reducing experimental variability.
12/Oct/2023
A*a: Customized ADGRE1 truncation variants were delivered with precise post-translational modifications.
17/Feb/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
ADGRE1 Knockout for Immune Modulation
Creative Biolabs offers ADGRE1 knockout services. Genome editing represents a transformative approach to silence ADGRE1, a myeloid-specific receptor implicated in inflammatory pathologies. By designing single-guide RNAs complementary to ADGRE1 exons, researchers can induce precise frameshift mutations, thereby ablating its surface expression in macrophages. This strategy has been validated in preclinical models of sepsis, where ADGRE1 knockout macrophages exhibited attenuated pro-inflammatory cytokine secretion, highlighting its therapeutic potential for hyperinflammatory disorders. Creative Biolabs' advanced sgRNA design and delivery optimization services ensure maximal on-target editing efficiency, enabling robust translational outcomes.
AAV-Driven ADGRE1 Overexpression
Creative Biolabs offers AAV-driven ADGRE1 overexpression services. Adeno-associated virus (AAV) vectors engineered with myeloid-specific promoters (e.g., CD68) enable selective ADGRE1 overexpression within tumor-associated macrophages (TAMs). Overexpression of ADGRE1 in murine TAMs has been shown to shift their polarization from a pro-tumorigenic M2 phenotype to an anti-tumor M1 state, facilitating tumor clearance in syngeneic models. This approach synergizes with checkpoint inhibitors, amplifying antitumor immunity. Creative Biolabs' expertise in cell-specific AAV capsid engineering ensures precise targeting of ADGRE1 within complex tumor microenvironments.
siRNA Nanocomplexes for Transient ADGRE1 Suppression
Creative Biolabs offers siRNA nanocomplexes development services. Lipid-polymer hybrid nanoparticles loaded with ADGRE1-specific siRNA enable transient silencing in circulating monocytes, reducing their infiltration into inflamed tissues. In murine autoimmune encephalitis models, intravenously administered nanocomplexes diminished ADGRE1+ monocyte recruitment to the central nervous system, alleviating neuroinflammation. Creative Biolabs' customizable nanoparticle formulations optimize biodistribution and endosomal escape, ensuring potent gene silencing with minimal off-target effects.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADGRE1 cell therapy. Please for more services.
CAR-Macrophage Engineering
Creative Biolabs offers CAR-macrophage engineering services. Chimeric antigen receptor (CAR)-macrophages targeting ADGRE1 epitopes have demonstrated enhanced phagocytic activity against ADGRE1+ immunosuppressive cells in solid tumors. For instance, CAR-macrophages expressing an ADGRE1-binding scFv domain effectively lysed myeloid-derived suppressor cells (MDSCs) in co-culture assays, restoring cytotoxic T-cell function. Creative Biolabs' proprietary CAR construct libraries and ex vivo macrophage differentiation protocols streamline the development of such therapies for clinical evaluation.
ADGRE1+ Monocyte Isolation and Ex Vivo Reprogramming
Creative Biolabs offers ADGRE1+ monocyte isolation and ex vivo reprogramming services. Magnetic-activated cell sorting (MACS), leveraging ADGRE1-specific antibodies, enables the isolation of patient-derived monocytes for ex vivo reprogramming. These cells can be polarized into anti-inflammatory macrophages using cytokine cocktails (e.g., IL-10/TGF-β) and reinfused to mitigate conditions like rheumatoid arthritis. Creative Biolabs' GMP-compliant cell isolation and culture systems ensure high purity and viability, accelerating therapeutic scalability.
Genetically Modified HSCs
Creative Biolabs offers genetically modified HSCs development services. Lentiviral transduction of HSCs with ADGRE1-targeted shRNA or overexpression constructs enables long-term modulation upon engraftment. In murine models, HSCs expressing ADGRE1 shRNA reduced systemic macrophage-driven inflammation, while ADGRE1-overexpressing HSCs enhanced pathogen clearance in chronic infections. Creative Biolabs' lentiviral vector platforms and hematopoietic differentiation assays provide end-to-end support for such regenerative approaches.
The path from target validation to clinical translation demands precision tools and multidisciplinary collaboration. Creative Biolabs' integrated solutions—spanning gene editing, AAV engineering, and CAR-cell development—are engineered to overcome bottlenecks in ADGRE1-focused drug discovery. Please feel free to to design a bespoke development strategy, leveraging our two decades of experience in antibody and cell therapy innovation. Let us catalyze your next breakthrough.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
