Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adhesion G protein-coupled receptor E2 |
| Gene Name | ADGRE2 |
| Uniprot | Q9UHX3 (Human) |
| Synonym | VBU; CD97; EMR2; CD312; CD97 antigen; EGF-like module-containing mucin-like hormone receptor-like 2; Leukocyte antigen CD97; egf-like module containing, mucin-like, hormone receptor-like 2 |
| Background | ADGRE2, also known as EGF-like module receptor 2 (EMR2) or EGF-like module-containing mucin-like hormone receptor-like 2, is a protein encoded by the human ADGRE2 gene. As a member of the adhesion GPCR family, it is characterized by an extended extracellular region often possessing N-terminal protein modules that are linked to a TM7 region via a domain known as the GPCR-Autoproteolysis Inducing (GAIN) domain. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX404 | NativeExtract™ Human ADGRE2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3662K | MemDX™ Membrane Protein Human ADGRE2 Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| MPX0020K | MemDX™ Membrane Protein Human ADGRE2 Expressed in CHO for Antibody Discovery, Partial (24-478aa) | CHO cells | Partial | N/A |
| S01YF-0423-KX415 | MemDX™ Membrane Protein Human ADGRE2 (24-537aa) Expressed in HEK293, C-7×His tag | HEK293 cells | Partial | N/A |
| Please for more products or customization | ||||
E***yn: Creative Biolabs' ADGRE2 protein is ideal for receptor-ligand interaction studies, with reliable batch consistency and clear technical documentation.
05/Mar/2023
G***e: Perfect for niche assay development requiring tailored constructs.
12/Dec/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
ADGRE2 Gene Editing
Creative Biolabs offers gene editing services. Precision genome engineering offers transformative potential for modulating ADGRE2, a cell surface protein implicated in macrophage-mediated immune responses. By designing RNAs complementary to ADGRE2's extracellular domains, researchers can disrupt or knock out its expression in myeloid-derived suppressor cells (MDSCs), thereby attenuating immunosuppressive tumor microenvironments. Creative Biolabs' proprietary RNA design platform optimizes specificity and efficiency, minimizing off-target effects while ensuring robust editing outcomes. Such advancements underscore the viability of ADGRE2 as a genetic target for next-generation immunotherapies.
ADGRE2 Overexpression
Creative Biolabs offers ADGRE2 overexpression services. Adeno-associated virus (AAV) vectors engineered with tissue-specific promoters enable localized ADGRE2 overexpression in inflamed tissues, a strategy with therapeutic promise for autoimmune conditions. By leveraging AAV9's tropism for synovial macrophages, for example, researchers have achieved sustained ADGRE2 upregulation in rheumatoid arthritis models, resulting in reduced pro-inflammatory cytokine secretion and joint destruction. Creative Biolabs' expertise in capsid optimization ensures targeted delivery, while our in-house qPCR and flow cytometry services validate transduction efficiency. This approach exemplifies how controlled ADGRE2 modulation can recalibrate immune homeostasis, offering a pathway to address diseases driven by dysregulated macrophage activity.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADGRE2 cell therapy. Please for more services.
ADGRE2-Specific CAR-Macrophage Engineering
Creative Biolabs offers ADGRE2-specific CAR-macrophage engineering services. Chimeric antigen receptor (CAR)-macrophages engineered to target ADGRE2 epitopes represent a breakthrough in cell therapy for malignancies resistant to conventional treatments. By coupling ADGRE2-binding scFv domains with intracellular signaling motifs (e.g., CD3ζ and co-stimulatory domains), these modified macrophages acquire enhanced phagocytic activity against ADGRE2+ tumor cells. Creative Biolabs' lentiviral vector development services support stable CAR integration, while our single-cell RNA sequencing platforms characterize functional polarization post-modification. Recent in vivo data reveal that ADGRE2-targeted CAR macrophages significantly reduce metastatic burden in triple-negative breast cancer models, highlighting their therapeutic potential.
ADGRE2-Directed Stem Cell Modulation for Tissue Regeneration
Creative Biolabs offers ADGRE2-directed stem cell modulation for tissue regeneration services. ADGRE2's role in modulating stromal cell interactions positions it as a critical target for stem cell-based regenerative therapies. Induced pluripotent stem cells (iPSCs) edited to overexpress ADGRE2 exhibit enhanced adhesion to fibrotic extracellular matrix components, improving engraftment efficiency in myocardial infarction models. Creative Biolabs' gene-editing services streamline ADGRE2 integration, and our high-content imaging systems track real-time cell-matrix interactions. This methodology not only accelerates tissue repair but also provides a scaffold for combinatorial therapies, such as cytokine delivery via engineered exosomes.
As ADGRE2 emerges as a pivotal target in immuno-oncology and regenerative medicine, Creative Biolabs' end-to-end solutions—from RNA design and viral vector development to functional validation—empower researchers to translate discoveries into clinical breakthroughs. To explore how our tailored services can advance your ADGRE2-focused programs, please feel free to for a comprehensive consultation.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
