Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adhesion G protein-coupled receptor E3 |
| Gene Name | ADGRE3 |
| Uniprot | Q9BY15 (Human) |
| Synonym | EMR3; EGF-like module receptor 3; EGF-like module-containing mucin-like hormone receptor-like 3; egf-like module containing, mucin-like, hormone receptor-like 3; egf-like module-containing mucin-like receptor 3 |
| Background | ADGRE3, also known as EGF-like module receptor 3 (EMR3) or EGF-like module-containing mucin-like hormone receptor-like 3, is a protein encoded by the human ADGRE3 gene. As a member of the adhesion GPCR family, ADGRE3 is expressed at the cell surface as a heterodimeric molecule consisting of a long extracellular α-chain, which possesses an N-terminus EGF-like domain and a membrane-spanning β-chain. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX317 | NativeExtract™ Human ADGRE3 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3165K | MemDX™ Membrane Protein Human ADGRE3 Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
S***ia: Highly recommend for membrane protein research.
19/Jul/2023
L*o: Outstanding service for tailored ADGRE3 production. Specifications matched experimental needs (tag placement, buffer optimization).
04/Feb/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Gene Editing for ADGRE3 Dysregulation
Creative Biolabs offers gene editing services for ADGRE3 dysregulation. ADGRE3, a critical adhesion G protein-coupled receptor implicated in immune cell migration and inflammatory pathologies, presents unique opportunities for therapeutic intervention. By leveraging in vivo homology-directed repair (HDR) systems, gene editing enables precise correction of gain-of-function mutations within the ADGRE3 locus observed in chronic inflammatory disorders. Creative Biolabs' proprietary RNA design platforms enhance specificity, minimizing off-target effects in complex genomic landscapes. Such innovations empower researchers to dissect ADGRE3's role in disease progression and accelerate therapeutic candidate selection.
AAV-Driven ADGRE3 Knockdown
Creative Biolabs offers AAV-driven ADGRE3 knockdown services. Adeno-associated virus (AAV) vectors engineered with tissue-specific promoters enable localized delivery of short hairpin RNA (shRNA) to suppress ADGRE3 overexpression in disease microenvironments. In a proof-of-concept study, intra-articular AAV9-shRNA administration in rheumatoid arthritis models reduced synovial ADGRE3 mRNA levels by 80%, correlating with diminished cartilage degradation. Creative Biolabs' AAV serotype optimization services ensure maximal tropism for immune-cell-rich tissues, enhancing translational potential.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADGRE3 cell therapy. Please for more services.
CAR-T Cells Targeting ADGRE3+ Immune Cells
Creative Biolabs offers CAR-T cells engineering services targeting ADGRE3+ immune cells. ADGRE3's ectodomain overexpression on pathogenic T-cell subsets in autoimmune diseases positions it as an ideal candidate for CAR-T cell therapies. By engineering autologous T cells with ADGRE3-specific scFv domains, researchers can selectively deplete hyperactive immune populations. In a murine lupus nephritis model, ADGRE3-CAR-T infusion reduced autoreactive CD4+ T-cell counts by 70% while preserving regulatory T-cell function. Creative Biolabs' CAR construct validation services, including flow cytometry-based efficacy screens, ensure robust target engagement and safety profiles for first-in-human trials.
ADGRE3-Modified MSCs for Anti-Inflammatory Delivery
Creative Biolabs offers ADGRE3-modified MSCs for anti-inflammatory delivery services. Mesenchymal stem cells (MSCs) transduced with ADGRE3-suppressive vectors secrete anti-inflammatory cytokines (e.g., IL-10, TGF-β) directly into inflamed tissues. In a recent osteoarthritis study, intra-articular injection of ADGRE3-silenced MSCs decreased prostaglandin E2 synthesis by 50%, mitigating pain and joint damage. Creative Biolabs' lentiviral transduction platforms enable stable ADGRE3 modulation in MSCs, ensuring consistent cytokine production. Collaborative partnerships with our experts can streamline IND-enabling studies for this approach.
The molecular complexity of ADGRE3 demands bespoke gene editing and cell engineering strategies. Creative Biolabs' two decades of expertise in antibody development and protein analytics provide unparalleled support for target validation, vector design, and preclinical profiling. Please feel free to to explore how our gene editing, AAV, and CAR-T cell development services can accelerate your ADGRE3 therapeutic program. From target discovery to clinical translation, we deliver scientifically rigorous, scalable solutions tailored to your research goals.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
