Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adhesion G protein-coupled receptor G5 |
| Gene Name | ADGRG5 |
| Uniprot | Q8IZF4 (Human); Q3V3Z3 (Mouse) |
| Synonym | PGR27; GPR114; G protein-coupled receptor 114; G protein-coupled receptor PGR27; probable G-protein coupled receptor 114 |
| Background | ADGRG5, also known as G-protein coupled receptor 114 (GPR114) or G-protein coupled receptor PGR27 (PGR27), is a protein encoded by the ADGRG5 gene. It is a member of the adhesion GPCR family which are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX309 | NativeExtract™ Human ADGRG5 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3615K | MemDX™ Membrane Protein Human ADGRG5 Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| MP0438X | MemDX™ Membrane Protein Human ADGRG5 (Adhesion G protein-coupled receptor G5) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MPX0022K | MemDX™ Membrane Protein Human ADGRG5 Expressed in CHO for Antibody Discovery, Partial (22-184aa) | CHO cell | Partial | N/A |
| Please for more products or customization | ||||
R***n: Highly recommended for high-throughput screening.
22/Nov/2023
Q***n: Custom ADGRG5 with N-terminal His-tag and mammalian expression was delivered promptly.
14/Jun/2024
ADGRG5 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
Gene Knockout
Creative Biolabs offers gene knockout services. Therapeutic strategies targeting ADGRG5—a member of the adhesion G protein-coupled receptor family—have leveraged gene editing technology to disrupt its expression in oncogenic contexts. For instance, knockout of ADGRG5 in colorectal carcinoma models has demonstrated significant attenuation of tumor invasiveness by modulating Wnt/β-catenin signaling. Creative Biolabs' proprietary RNA libraries and validation platforms enable precise genomic editing, ensuring high specificity for ADGRG5 while minimizing off-target effects. Such approaches not only elucidate the receptor's pathophysiological role but also identify candidate patient populations for tailored therapies.
AAV-Driven Overexpression for Tissue Regeneration
Creative Biolabs offers AAV-driven overexpression services for tissue regeneration. Adeno-associated virus (AAV) vectors engineered to deliver ADGRG5 under tissue-specific promoters have shown promise in mucosal repair applications. Preclinical studies in inflammatory bowel disease models reveal that AAV-mediated ADGRG5 overexpression enhances epithelial barrier integrity by upregulating tight junction proteins. Creative Biolabs' custom AAV serotype libraries, optimized for gastrointestinal tropism, ensure efficient transduction in complex tissue microenvironments. This strategy highlights the dual utility of ADGRG5 modulation in both therapeutic intervention and mechanistic validation.
siRNA Silencing for Metastatic Suppression
Creative Biolabs offers siRNA silencing services. Small interfering RNA (siRNA) constructs targeting ADGRG5 have been employed to suppress metastasis in triple-negative breast cancer. Lipid nanoparticle formulations delivering ADGRG5-specific siRNAs significantly reduce lymphatic invasion by inhibiting CXCL12/CXCR4 chemokine axis crosstalk. Creative Biolabs' advanced siRNA design and delivery platforms—including proprietary stability-enhancing modifications—maximize therapeutic efficacy while addressing pharmacokinetic challenges.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADGRG5 cell therapy. Please for more services.
CAR-T Cell Engineering for Tumor Microenvironment Targeting
Creative Biolabs offers CAR-T cell engineering services. Chimeric antigen receptor (CAR) T cells engineered to recognize ADGRG5-expressing tumor-associated fibroblasts are emerging as a novel approach for solid tumor treatment. In pancreatic adenocarcinoma models, ADGRG5-directed CAR-T cells selectively deplete stromal components that contribute to immunosuppression, thereby enhancing chemotherapy penetration. Creative Biolabs' CAR construct optimization services, featuring high-affinity scFv domains and tunable co-stimulatory signaling, accelerate the development of such precision therapies.
Mesenchymal Stem Cell (MSC) Secretome Modulation
Creative Biolabs offers MSC secretome modulation services. ADGRG5-modified mesenchymal stem cells have been utilized to modulate inflammatory cascades in rheumatoid arthritis. Lentiviral transduction of MSCs with ADGRG5 promotes the secretion of anti-inflammatory cytokines, such as IL-10, while suppressing TNF-α production in synovial tissue. Creative Biolabs' lentiviral vector development services, characterized by high transduction efficiency and rigorous biosafety profiling, support the generation of clinically viable cell products.
Dendritic Cell Vaccines for Immune Activation
Creative Biolabs offers dendritic cell vaccines development services for immune activation. ADGRG5 peptide-pulsed dendritic cell vaccines are being explored to enhance antitumor immunity in ADGRG5-overexpressing malignancies. Phase I trials in melanoma demonstrate robust CD8+ T cell responses against ADGRG5 epitopes, correlating with reduced recurrence rates. Creative Biolabs' antigen discovery and MHC-binding prediction tools streamline epitope selection, ensuring maximal immunogenicity for such vaccines.
The intricate interplay between ADGRG5 and diverse disease pathways underscores its viability as a therapeutic target. Creative Biolabs' end-to-end solutions empower researchers to overcome technical barriers and accelerate preclinical-to-clinical translation. Please feel free to to design a bespoke ADGRG5 development strategy tailored to your program's unique needs. Whether optimizing viral vectors or refining cell-based delivery systems, our expertise ensures your innovations achieve their full therapeutic potential.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
