Introduction of ADGRL1
ADGRL1, also known as Calcium-independent alpha-latrotoxin receptor 1 or Latrophilin-1 (LPHN1), is a protein encoded by the human ADGRL1 gene. As a member of the novel family of G protein-coupled receptors which previously thought to be brain-specific, ADGRL1 is characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
|Basic Information of ADGRL1|
|Protein Name||Adhesion G protein-coupled receptor L1|
|Aliases||Calcium-independent alpha-latrotoxin receptor 1, CIRL-1, Latrophilin-1, Lectomedin-2|
|Organism||Homo sapiens (Human)|
Function of ADGRL1 Membrane Protein
ADGRL1 (calcium-independent receptor of a-latrotoxin) is a neuronal G protein-coupled receptor with the large N-terminal ectodomain containing mosaics of cell adhesion modules. It was originally discovered as a target of potent presynaptic neurotoxin, latrotoxin, and has been shown to regulate secretion. Studies have shown that ADGRL1 consists of two heterologous subunits, p120 which is an extracellular hydrophilic polypeptide and p85 - a heptahelical membrane protein. Both CIRL-1 subunits are encoded by one gene and derive from proteolytically processed receptor precursor. Moreover, ADGRL1 is associated with the processes of cell adhesion and signal transduction. It has also been reported that ADGRL1 is involved in the release of hormones, including the release of neurotransmitters from sensory and motor neurons, and also for the release of insulin from endocrine cells.
Fig.1 Crystal structure of the GAIN and HormR domains of Latrophilin 1.
Application of ADGRL1 Membrane Protein in Literature
1. Deyev IE., Petrenko AG. Regulation of CIRL-1 proteolysis and trafficking. Biochimie. 2010, 92(4): 418-22. PubMed ID: 20100540
This article suggests that the GPS proteolysis of CIRL-1 is not a purely autocatalytic process and may involve auxiliary proteins or factors that become available in the course of CIRL-1 trafficking.
2. Zuko A., et.al. Association of cell adhesion molecules contactin-6 and latrophilin-1 regulates neuronal apoptosis. Frontiers in molecular neuroscience. 2016, 9: 143. PubMed ID: 28018171
This article suggests that the cell adhesion molecule contactin-6 (Cntn6) can modulate the activity of Lphn1 by direct binding and indicates that Cntn6 may prevent apoptosis thereby impinging on neurodevelopment.
ADGRL1 Preparation Options
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