Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsAdhesion G-protein coupled receptors (adhesion GPCRs) are consist of a class of protein receptors with a broad distribution in embryonic and larval cells, cells of the reproductive tract, neurons, leukocytes, and a variety of tumors. They are characterized by very long N-terminal regions which comprise a variety of modular adhesion domains, including epidermal growth factor-like repeats, and cadherin-like repeats, among others. Vertebrate genomes encode a number of members of this family, comprising 33 members in humans and 31 members in mice. Importantly, certain invertebrates restrain a dramatic expansion of this family, especially sea urchins, which express about 100 different adhesion GPCRs. Moreover, the adhesion GPCR family can be subdivided into some subfamilies, based on sequence similarity.
Here shows part of adhesion GPCRs in humans including brain-specific angiogenesis inhibitors, EGF-like module receptors, calcium-independent alpha-latrotoxin receptors, etc. There are also some orphan receptors in this family and work is underway to de-orphanize them. They are named adhesion GPCRs for they have adhesion-like N-terminal domains. But their ligands are still not known.
| Human Adhesion GPCR Members | ||||
| ADGRA2 | ADGRA3 | ADGRB1 | ADGRB2 | ADGRB3 |
| ADGRD1 | ADGRE1 | ADGRE2 | ADGRE3 | ADGRE4P |
| ADGRF1 | ADGRF5 | ADGRG1 | ADGRG2 | ADGRG3 |
| ADGRG5 | ADGRG6 | ADGRL1 | ADGRL3 | ADGRL4 |
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. Creative Biolabs also presents anti-membrane protein antibody production by DNA immunization services. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
