Adhesion G-protein coupled receptors (adhesion GPCRs) are consist of a class of protein receptors with a broad distribution in embryonic and larval cells, cells of the reproductive tract, neurons, leukocytes, and a variety of tumors. They are characterized by very long N-terminal regions which comprise a variety of modular adhesion domains, including epidermal growth factor-like repeats, and cadherin-like repeats, among others. Vertebrate genomes encode a number of members of this family, comprising 33 members in humans and 31 members in mice. Importantly, certain invertebrates restrain a dramatic expansion of this family, especially sea urchins, which express about 100 different adhesion GPCRs. Moreover, the adhesion GPCR family can be subdivided into some subfamilies, based on sequence similarity.
Here shows part of adhesion GPCRs in humans including brain-specific angiogenesis inhibitors, EGF-like module receptors, calcium-independent alpha-latrotoxin receptors, etc. There are also some orphan receptors in this family and work is underway to de-orphanize them. They are named adhesion GPCRs for they have adhesion-like N-terminal domains. But their ligands are still not known.
|Human Adhesion GPCR Members|
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